Lysophospholipid mediators: Their receptors and synthetic pathways

Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu, Yuji Shinjo, Kahori Namiki, Hiroki Kawana, Saki Nemoto, Hirotaka Matsumoto, Ryoji Kise, Asuka Inoue, Junken Aoki

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo. In addition, recent studies have identified several GPCRs for other lysophospholipids such as lysophosphatidylserine (LysoPS) andlysophosphatidylinositol (LPI). In this chapter, we summarize the actions and production of these LPLs as lipid mediators including LysoPS and LPI.

Original languageEnglish
Title of host publicationBioactive Lipid Mediators
Subtitle of host publicationCurrent Reviews and Protocols
PublisherSpringer Japan
Pages109-126
Number of pages18
ISBN (Electronic)9784431556695
ISBN (Print)9784431556688
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Autotaxin
  • G protein-coupled receptors (GPCRs)
  • Lysophosphatidic acid
  • Lysophosphatidylserine
  • Lysophospholipids
  • Phosphatidic acid-selective phospholipase A 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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