Lysophosphatidylcholine generates superoxide anions through activation of phosphatidylinositol 3-kinase in human neutrophils

Hiroaki Nishioka, Hisanori Horiuchi, Hidenori Arai, Toru Kita

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Lysophosphatidylcholine (LPC) accumulates in inflammatory tissues, where neutrophils are recruited to generate superoxide anions (O(·-)2). Here, we show that LPC stimulates O(·-)2 generation in human neutrophils and that the activity is inhibited with phosphatidylinositol 3-kinase (PI3 kinase) inhibitors, but not with protein kinase C (PKC) inhibitors. Furthermore, we demonstrate that LPC activates PI3 kinase in neutrophils. Thus, LPC might contribute to host defense by generating O(·-)2 in neutrophils through PI3 kinase activation, but not through PKC activation. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalFEBS Letters
Volume441
Issue number1
DOIs
Publication statusPublished - 1998 Dec 11

Keywords

  • Lysophosphatidylcholine
  • Neutrophil
  • Phosphatidylinositol 3-kinase
  • Protein kinase C
  • Superoxide anion

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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