Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

Yusuke Sato; Hiroki Saito; Daisuke Aoki; Norio Teramae; Seiichi Nishizawa

doi:10.1039/c6cc07236d

Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

Yusuke Sato, Hiroki Saito, Daisuke Aoki, Norio Teramae, Seiichi Nishizawa

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.

Original language	English
Pages (from-to)	14446-14449
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	100
DOIs	https://doi.org/10.1039/c6cc07236d
Publication status	Published - 2016

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c6cc07236d

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title = "Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids",

abstract = "Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.",

author = "Yusuke Sato and Hiroki Saito and Daisuke Aoki and Norio Teramae and Seiichi Nishizawa",

note = "Funding Information: This work was supported by Grant-in-Aids for Scientific Research (S) (No. 22225003) and (B) (No. 24350033) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by a grant from the Center of Innovation Program from Japan Science and Technology, JST. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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doi = "10.1039/c6cc07236d",

language = "English",

volume = "52",

pages = "14446--14449",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

AU - Sato, Yusuke

AU - Saito, Hiroki

AU - Aoki, Daisuke

AU - Teramae, Norio

AU - Nishizawa, Seiichi

N1 - Funding Information: This work was supported by Grant-in-Aids for Scientific Research (S) (No. 22225003) and (B) (No. 24350033) from the Ministry of Education, Culture, Sports, Science and Technology, Japan, and by a grant from the Center of Innovation Program from Japan Science and Technology, JST. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2016

Y1 - 2016

N2 - Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.

AB - Introduction of lysine linkage in the conjugate between abasic site-binding ligands and thiazole orange significantly improved the binding affinity for target orphan adenine or uracil nucleobase in DNA/RNA hybrids.

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U2 - 10.1039/c6cc07236d

DO - 10.1039/c6cc07236d

M3 - Article

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AN - SCOPUS:85006289287

VL - 52

SP - 14446

EP - 14449

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 100

ER -

Lysine linkage in abasic site-binding ligand-thiazole orange conjugates for improved binding affinity to orphan nucleobases in DNA/RNA hybrids

Abstract

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