In order to establish the exact method for detection of onset of acute allograft rejection in lung transplantation, attempts were made to evaluate serial non-specific lymphocyte blastogenesis tests including PHA (phytohemagglutinin) response and spontaneous blastogenesis of peripheral lymphocyte. The recipient of lung allotransplantation showed a decreased response to PHA (P < 0.05) and an increased spontaneous blastogenesis (P < 0.001) at the period of allograft rejection as compared to those obtained preoperatively, whereas the histologic findings of the lung transplant always revealed a manifestation of rejection. In many cases, these phenomena were not infrequently correlated and preceded to the rejection episode detected on serial chest X-ray films, whereas there were no particular changes in both parameters of dogs bearing enhanced allografts. A specific lymphocyte function test should be necessary to differentiate a rejection from an infection phenomenon which is apt to occur in the transplanted lung; however, we believe that serial detection of spontaneous blastogenesis as we studied in this paper could be one of the useful methods for early prediction of rejection episode in lung transplantation.
|Number of pages||9|
|Journal||Science Reports of the Research Institutes Tohoku University - Series C Medicine|
|Publication status||Published - 1981|
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