Lymphatic transport of cholesterol in normocholesterolemic rats treated with pravastatin, an inhibitor of HMG-CoA reductase

Masanobu Sakono, Toko Ibi, Koji Nagao, Ikuo Ikeda, Kyosuke Yamamoto, Katsumi Imaizumi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Lymphatic absorption and transport of cholesterol and triacylglycerols were examined in rats treated with pravastatin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. Pravastatin-treatment for 1, 7 and 28 days did not affect the recovery of cholesterol and triacylglycerols during 24 h after the lipid administration: the recovery was 52-59% and 82-93% for cholesterol and triacylglycerols, respectively. Rats treated with pravastatin for 28 days had a higher lymphatic recovery of the lipids during 3-6 h after the lipid administration than did control rats. Pravastatin treatment did not affect the ratio of phospholipid to cholesterol in the gut mucosa, the fatty acid composition of the lymph and mucosal lipids. We concluded that an inhibitor of HMG-CoA reductase would exert no adverse effect on absorption of fat-soluble nutrients by gut.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalAtherosclerosis
Volume124
Issue number1
DOIs
Publication statusPublished - 1996 Jul
Externally publishedYes

Keywords

  • Inhibitor of HMG-CoA reductase
  • Lymphatic transport of cholesterol
  • Pravastatin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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