Lymphatic transport of α-, γ-, and δ-tocotrienols and α-tocopherol in rats

Ikuo Ikeda, Youji Imasato, Eiji Sasaki, Michihiro Sugano

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62 Citations (Scopus)

Abstract

Lymphatic transport of α-, γ- and δ- tocotrienols and α-tocopherol was measured in thoracic duct-cannulated rats. Animals were administered 3 ml of a test emulsion containing 200 mg sodium taurocholate, 50 mg fatty acid free-albumin, 200 mg fat and 100 mg of a mixture of tocotrienols and α- tocopherol (Exp. 1) or 10 mg of purified α-, γ- or δ-tocotrienol or α- tocopherol (Exp. 2) through a gastric tube. Quantitative lymphatic recovery of oleic acid given as triolein was obtained in these experimental conditions. The 24-hours recovery of tocotrienols and α-tocopherol were 10- 20% of the administered doses in Exp. 1. The recovery of α-tocotrienol was bout 2-times higher than that of α-tocopherol, while that of γ- and δ- tocotrienols was intermediate between these two α-forms. In Exp. 2, where these compounds were administered individually, the 24 hours recovery ranged from 22 to 37% of the administered dose. Again, the recovery of α- tocotrienol was significantly higher than that of the other tocotrienols and α-tocopherol, while that of γ- and δ-tocotrienols and α-tocopherol was comparable. Thus, the results show the preferential absorption of α- tocotrienol compared to γ- and δ-tocotrienols and α-tocopherol.

Original languageEnglish
Pages (from-to)217-221
Number of pages5
JournalInternational Journal for Vitamin and Nutrition Research
Volume66
Issue number3
Publication statusPublished - 1996 Nov 14
Externally publishedYes

Keywords

  • Absorption
  • Lymph
  • Rats
  • Tocopherol
  • Tocotrienols

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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