Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini

Yasuhiro Igarashi, Saeko Yanase, Kohei Sugimoto, Masaru Enomoto, Satoshi Miyanaga, Martha E. Trujillo, Ikuo Saiki, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.

Original languageEnglish
Pages (from-to)862-865
Number of pages4
JournalJournal of Natural Products
Issue number4
Publication statusPublished - 2011 Apr 25

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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