Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini

Yasuhiro Igarashi, Saeko Yanase, Kohei Sugimoto, Masaru Enomoto, Satoshi Miyanaga, Martha E. Trujillo, Ikuo Saiki, Shigefumi Kuwahara

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A new anthraquinone derivative, lupinacidin C (1), was isolated from the endophytic actinomycete Micromonospora lupini. The structure was elucidated on the basis of spectroscopic analyses, and the absolute configuration was determined by total synthesis. Lupinacidin C (1) exhibited the most potent inhibitory effects among the congeners on the invasion of murine colon carcinoma cells into the reconstituted basement membrane.

Original languageEnglish
Pages (from-to)862-865
Number of pages4
JournalJournal of Natural Products
Volume74
Issue number4
DOIs
Publication statusPublished - 2011 Apr 25

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Lupinacidin C, an inhibitor of tumor cell invasion from micromonospora lupini'. Together they form a unique fingerprint.

  • Cite this