Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats

Ardiansyah, Eri Yamaguchi, Hitoshi Shirakawa, Keishi Hata, Kazuyuki Hiwatashi, Kousaku Ohinata, Tomoko Goto, Michio Komai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Supplementation with lupeol (0.67 g·kg -1) of the AIN- 93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume76
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Blood pressure
  • Lipid metabolism
  • Lupeol
  • Stroke-prone spontaneously hypertensive rat

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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