Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats

Ardiansyah, Eri Yamaguchi, Hitoshi Shirakawa, Keishi Hata, Kazuyuki Hiwatashi, Kousaku Ohinata, Tomoko Goto, Michio Komai

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    Supplementation with lupeol (0.67 g·kg -1) of the AIN- 93M-based diet fed for 7 weeks to stroke-prone spontaneously hypertensive rats caused significantly decreased blood pressure as compared with a control group. Urinary 8-hydroxy-2'-deoxyguanosine was significantly lower in the lupeol group. Finally, lupeol suppressed the hepatic mRNA expression levels of the genes involved in triglyceride and cholesterol synthesis.

    Original languageEnglish
    Pages (from-to)183-185
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume76
    Issue number1
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Blood pressure
    • Lipid metabolism
    • Lupeol
    • Stroke-prone spontaneously hypertensive rat

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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