Lung tumor imaging by positron emission tomography using C-11 L-methionine

K. S. Kubota, T. Matsuzawa, M. Ito, T. Fujiwara, Y. Abe, S. Yoshioka, H. Fukuda, J. Hatazawa, Ren Iwata

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)


This paper described the first clinical study of lung tumor scanning by positron emission tomography (PET) using C-11-labeled L-methionine (11C-L-Met). Tumor images were clearly visualized by high contrast in eight lung cancer patients and also in a patient with a silicotic nodule. Quantitative evaluations of methionine uptake in tumor tissue and normal tissue by comparing differential uptake ratios suggested that the extent to which 11C-L-Met accumulates in a tumor is closely correlated to the tumor's viability such as benign or malignant, viable or necrotic. 11C-L-Met is considered to be an effective tumors in the mediastinum and lung.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalJournal of Nuclear Medicine
Issue number1
Publication statusPublished - 1985 Apr 4

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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