LSI-based electrochemical device for evaluation of respiratory activity of three-dimensional cultured cells

Kosuke Ino, Takehiro Onodera, Hitoshi Shiku

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In the study, an amperometric LSI-based device containing 400 sensors with a 250-μm pitch was applied for electrochemical imaging of respiratory activity of three-dimensional (3D) cultured osteosarcoma cells as a bone model. The electrochemical imaging is based on detection of oxygen reduction currents. The electrochemical images showed that the oxygen reduction currents decreased near the cell aggregates, indicating that the imaging was successfully applied for evaluation of respiration activity.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages477-478
Number of pages2
ISBN (Electronic)9780692941836
Publication statusPublished - 2020 Jan 1
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 2017 Oct 222017 Oct 26

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period17/10/2217/10/26

Keywords

  • Cell analysis
  • Electrochemical bioimaging
  • Electrode array device
  • Respiratory activity

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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