Low temperature Sonogashira coupling reaction

Keiichi Nakamura, Hitoshi Okubo, Masahiko Yamaguchi

Research output: Contribution to journalArticle

79 Citations (Scopus)


A low temperature Sonogashira reaction was developed, which coupled equimolar amount of aryl iodide possessing electron-withdrawing groups with aromatic acetylene at -20 °C in quantitative yield.

Original languageEnglish
Pages (from-to)549-550
Number of pages2
Issue number5
Publication statusPublished - 1999 Jan 1


  • Aryl iodide
  • N- BuNI
  • Sonogashira coupling reaction
  • Tris(2,4,6trimethylphenyl)phosphine

ASJC Scopus subject areas

  • Organic Chemistry

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    Nakamura, K., Okubo, H., & Yamaguchi, M. (1999). Low temperature Sonogashira coupling reaction. Synlett, (5), 549-550. https://doi.org/10.1055/s-1999-2684