Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

S. Yaegashi; R. Sachse; Noriaki Ohuchi; S. Mori; T. Sekiya

Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

S. Yaegashi, R. Sachse, Noriaki Ohuchi, S. Mori, T. Sekiya

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

Original language	English
Pages (from-to)	929-933
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	86
Issue number	10
Publication status	Published - 1995 Jan 1

Keywords

Human breast cancer
Mutation
NF2 gene
Polymorphism
SSCP analysis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers",

abstract = "We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.",

keywords = "Human breast cancer, Mutation, NF2 gene, Polymorphism, SSCP analysis",

author = "S. Yaegashi and R. Sachse and Noriaki Ohuchi and S. Mori and T. Sekiya",

year = "1995",

month = jan,

day = "1",

language = "English",

volume = "86",

pages = "929--933",

journal = "Cancer Science",

issn = "1347-9032",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

AU - Yaegashi, S.

AU - Sachse, R.

AU - Ohuchi, Noriaki

AU - Mori, S.

AU - Sekiya, T.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

AB - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

KW - Human breast cancer

KW - Mutation

KW - NF2 gene

KW - Polymorphism

KW - SSCP analysis

UR - http://www.scopus.com/inward/record.url?scp=85004899686&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85004899686&partnerID=8YFLogxK

M3 - Article

VL - 86

SP - 929

EP - 933

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 10

ER -

Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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