Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

S. Yaegashi, R. Sachse, Noriaki Ohuchi, S. Mori, T. Sekiya

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

Original languageEnglish
Pages (from-to)929-933
Number of pages5
JournalJapanese Journal of Cancer Research
Volume86
Issue number10
Publication statusPublished - 1995 Jan 1

Keywords

  • Human breast cancer
  • Mutation
  • NF2 gene
  • Polymorphism
  • SSCP analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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