Abstract
We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.
Original language | English |
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Pages (from-to) | 929-933 |
Number of pages | 5 |
Journal | Japanese Journal of Cancer Research |
Volume | 86 |
Issue number | 10 |
Publication status | Published - 1995 Jan 1 |
Keywords
- Human breast cancer
- Mutation
- NF2 gene
- Polymorphism
- SSCP analysis
ASJC Scopus subject areas
- Oncology
- Cancer Research