Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

S. Yaegashi; R. Sachse; Noriaki Ohuchi; S. Mori; T. Sekiya

Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

S. Yaegashi, R. Sachse, Noriaki Ohuchi, S. Mori, T. Sekiya

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

Original language	English
Pages (from-to)	929-933
Number of pages	5
Journal	Japanese Journal of Cancer Research
Volume	86
Issue number	10
Publication status	Published - 1995 Jan 1

Keywords

Human breast cancer
Mutation
NF2 gene
Polymorphism
SSCP analysis

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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abstract = "We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.",

keywords = "Human breast cancer, Mutation, NF2 gene, Polymorphism, SSCP analysis",

author = "S. Yaegashi and R. Sachse and Noriaki Ohuchi and S. Mori and T. Sekiya",

year = "1995",

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day = "1",

language = "English",

volume = "86",

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journal = "Cancer Science",

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TY - JOUR

T1 - Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

AU - Yaegashi, S.

AU - Sachse, R.

AU - Ohuchi, Noriaki

AU - Mori, S.

AU - Sekiya, T.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

AB - We investigated aberrations of the neurofibromatosis type 2 (NF2) gene in breast tumors of 60 patients by single-strand conformation polymorphism analysis of polymerase chain reaction products followed by nucleotide sequencing. We detected a tumor-specific single-base substitution in codon 398 in exon 12 of the gene, resulting in an alteration of a single amino acid, in DNA from a breast cancer sample. The results indicated possible but infrequent involvement of mutations of the tumor suppressor NF2 gene in human breast cancers.

KW - Human breast cancer

KW - Mutation

KW - NF2 gene

KW - Polymorphism

KW - SSCP analysis

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M3 - Article

VL - 86

SP - 929

EP - 933

JO - Cancer Science

JF - Cancer Science

SN - 1347-9032

IS - 10

ER -

Low incidence of a nucleotide sequence alteration of the neurofibromatosis 2 gene in human breast cancers

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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Cite this