TY - JOUR
T1 - Low HDL cholesterol is associated with the risk of stroke in elderly diabetic individuals
T2 - Changes in the risk for atherosclerotic diseases at various ages
AU - Hayashi, Toshio
AU - Kawashima, Seinosuke
AU - Itoh, Hideki
AU - Yamada, Nobuhiro
AU - Sone, Hirohito
AU - Watanabe, Hiroshi
AU - Hattori, Yoshiyuki
AU - Ohrui, Takashi
AU - Yokote, Koutaro
AU - Nomura, Hideki
AU - Umegaki, Hiroyuki
AU - Iguchi, Akihisa
PY - 2009/7
Y1 - 2009/7
N2 - OBJECTIVE - To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS - The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean ± SD age 67.4 ± 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD. RESULTS - IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects ≥65 years old and especially in those >75 years old (n = 1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result. CONCLUSIONS - Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals.
AB - OBJECTIVE - To clarify the relationship between lipid levels and ischemic heart disease (IHD) and cerebrovascular disease (CVD) in diabetic individuals. RESEARCH DESIGN AND METHODS - The Japan Cholesterol and Diabetes Mellitus Study is a prospective cohort study of 4,014 type 2 diabetic patients (1,936 women; mean ± SD age 67.4 ± 9.5 years). Lipid and glucose levels and other factors were investigated in relation to occurrence of IHD or CVD. RESULTS - IHD and CVD occurred in 1.59 and 1.43% of participants, respectively, over a 2-year period. The relation of lower HDL or higher LDL cholesterol to occurrence of IHD in subjects <65 years old was significant. Lower HDL cholesterol was also significantly related to CVD in subjects ≥65 years old and especially in those >75 years old (n = 1,016; odds ratio 0.511 [95% CI 0.239-0.918]; P < 0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed the same result. CONCLUSIONS - Lower HDL cholesterol is an important risk factor for not only IHD but also CVD, especially in diabetic elderly individuals.
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U2 - 10.2337/dc08-1677
DO - 10.2337/dc08-1677
M3 - Article
C2 - 19509009
AN - SCOPUS:67650034699
VL - 32
SP - 1221
EP - 1223
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 7
ER -
