Low-grade adenosquamous carcinoma of the breast: A case report with cytologic findings and review of the literature

Soichiro Shizawa, Hironobu Sasano, Takashi Suzuki, Hiroshi Ishii, Tetsutaro Takeda, Hiroshi Nagura

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14 Citations (Scopus)


The cytological and histopathological features of a case of low-grade adenosquamous carcinoma of the breast in a 47-year-old Japanese female was studied. The fine needle aspiration biopsy specimen of this case revealed proliferating ductal cells and atypical aquamous cells in the same cell clusters. The resected left breast mass had a relatively well-circumscribed hard mass measuring 1.6cm at its greatest dimension. Histologic examination demonstrated the coexistence of atypical squamous and ductal components in the same lesion, with transition between these two components. Desmoplastic stromal reaction was observed. The majority of ductal components had a two- layered composition, and sclerosing adenosis-like lesions were also observed at the periphery of the tumor. Based on these cytologic and histological findings, this tumor was diagnosed as low-grade adenosquemous carcinoma of the breast. This is the first report of the cytological findings of low- grade edenosquamous carcinoma of the breast, and it is important for pathologists to consider the possibility of low-grade adenosquamous carcinoma when the cytological findings described above are present in an aspiration cytology specimen of the breast.

Original languageEnglish
Pages (from-to)264-267
Number of pages4
JournalPathology international
Issue number4
Publication statusPublished - 1997


  • adenosquamous carcinoma
  • breast
  • cytology
  • low-grade

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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