TY - JOUR
T1 - Low-dose radiation-induced risk in spermatogenesis
AU - Fukunaga, Hisanori
AU - Butterworth, Karl T.
AU - Yokoya, Akinari
AU - Ogawa, Takehiko
AU - Prise, Kevin M.
N1 - Funding Information:
This work was supported by Nakayama Foundation for Human Science, Yokohama City University Gushinkai Alumni Association, Marubun Research Promotion Foundation. The funding organizations had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Funding Information:
This work was supported by Nakayama Foundation for Human Science, Yokohama City University Gushinkai Alumni Association, Marubun Research Promotion Foundation.
Funding Information:
This work was supported by Nakayama Foundation for Human Science, Yokohama City University Gushinkai Alumni Association, Marubun Research Promotion Foundation. This work was supported by Nakayama Foundation for Human Science, Yokohama City University Gushinkai Alumni Association, Marubun Research Promotion Foundation. The funding organizations had no role in the design and conduct of the study; in the collection, management, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/12/2
Y1 - 2017/12/2
N2 - Purpose: To discuss low-dose radiation-induced risks to male fertility focusing on potential mechanisms of low-dose radiation-induced damage on spermatogenesis, epidemiological studies of environmental radiation effects on sperm parameters and transgenerational effects following exposure of spermatogonial stem cells (SSCs). Background: Spermatogenesis produces mature male gametes, spermatozoa, which fertilize their counterpart female gametes, oocytes. The robust maintenance system of spermatogenesis is essential for genomic conservation; however, male fertility can be readily impacted by exposure to environmental, chemical and physical factors including ionizing radiation. The mammalian testes are known to be radiosensitive yet the underlying molecular mechanisms of low-dose radiation-induced risks for spermatogenesis remain unclear. Furthermore, evidence characterizing transgenerational effects following exposure of SSCs remain controversial. Conclusions: Current concerns over the possible effects of low-dose radiation exposure on spermatogenesis requires further elucidation that may be resolved comparing and integrating observed experimental and epidemiological data.
AB - Purpose: To discuss low-dose radiation-induced risks to male fertility focusing on potential mechanisms of low-dose radiation-induced damage on spermatogenesis, epidemiological studies of environmental radiation effects on sperm parameters and transgenerational effects following exposure of spermatogonial stem cells (SSCs). Background: Spermatogenesis produces mature male gametes, spermatozoa, which fertilize their counterpart female gametes, oocytes. The robust maintenance system of spermatogenesis is essential for genomic conservation; however, male fertility can be readily impacted by exposure to environmental, chemical and physical factors including ionizing radiation. The mammalian testes are known to be radiosensitive yet the underlying molecular mechanisms of low-dose radiation-induced risks for spermatogenesis remain unclear. Furthermore, evidence characterizing transgenerational effects following exposure of SSCs remain controversial. Conclusions: Current concerns over the possible effects of low-dose radiation exposure on spermatogenesis requires further elucidation that may be resolved comparing and integrating observed experimental and epidemiological data.
KW - Chernobyl nuclear accident
KW - Fukushima nuclear accident
KW - low-dose radiation-induced risk
KW - spermatogenesis
KW - transgenerational effect
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U2 - 10.1080/09553002.2017.1355579
DO - 10.1080/09553002.2017.1355579
M3 - Review article
C2 - 28764606
AN - SCOPUS:85026773030
VL - 93
SP - 1291
EP - 1298
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
SN - 0955-3002
IS - 12
ER -