Low-density lipoprotein cholesterol concentrations and death due to intraparenchymal hemorrhage: the ibaraki prefectural health study

Hiroyuki Noda, Hiroyasu Iso, Fujiko Irie, Toshimi Sairenchi, Emiko Ohtaka, Mikio Doi, Yoko Izumi, Hitoshi Ohta

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)

Abstract

BackgroundFew studies have examined the association between low levels of low-density lipoprotein (LDL) cholesterol and risk of intraparenchymal hemorrhage. Methods and ResultsA total of 30 802 men and 60 417 women, 40 to 79 years of age with no history of stroke or coronary heart disease, completed a aseline risk factor survey in 1993 under the auspices of the Ibaraki Prefectural Health Study. Systematic mortality surveillance was performed through 2003, and 264 intraparenchymal hemorrhage deaths were identified. LDL cholesterol levels were calculated with the Friedewald formula. Persons with LDL cholesterol 140 mg/dL had half the sex- and age-adjusted risk of death due to intraparenchymal hemorrhage of those with LDL cholesterol <80 mg/dL. After adjustment for cardiovascular risk factors, the multivariable hazard ratio compared with persons with LDL cholesterol <80 mg/dL was 0.65 (95% CI 0.44 to 0.96) for those with LDL cholesterol 80 to 99 mg/dL, 0.48 (0.32 to 0.71) for 100 to 119 mg/dL, 0.50 (0.33 to 0.75) for 120 to 139 mg/dL, and 0.45 (0.30 to 0.69) for 140 mg/dL. These inverse sociations were not altered substantially after the exclusion of persons with hypertriglyceridemia, after analysis with a Cox proportional hazard model with time-dependent covariates, or in sensitivity analysis for the potential effect of competing risks. ConclusionsLow LDL cholesterol levels are associated with elevated risk of death due to intraparenchymal hemorrhage. (Circulation. 2009;119:2136-2145.).

Original languageEnglish
Pages (from-to)2136-2145
Number of pages10
JournalCirculation
Volume119
Issue number16
DOIs
Publication statusPublished - 2009 Apr 28
Externally publishedYes

Keywords

  • Arteriosclerosis
  • Cholesterol
  • Follow-up studies
  • Intraparenchymal hemorrhage

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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