Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes

Tsutomu Shichishima, Kazuhiko Ikeda, Naoto Takahashi, Junichi Kameoka, Katsushi Tajima, Kazunori Murai, Yoshiko Tamai, Akiko Shichishima-Nakamura, Kazuko Akutsu, Hideyoshi Noji, Masatoshi Okamoto, Hideo Kimura, Hideo Harigae, Takashi Oyamada, Toyomi Kamesaki, Yasuchika Takeishi, Kenichi Sawada

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

To clarify whether measurement of serum haptoglobin (Hp) has impact on understanding pathophysiology in bone marrow failure (BMF) syndromes, we investigated concentrations of serum Hp by nephelometric procedure in 156 Japanese patients with BMF, including 54 aplastic anemia (AA), 50 paroxysmal nocturnal hemoglobinuria (PNH), and 52 myelodysplastic syndromes (MDS) patients. The frequencies with low concentrations of serum Hp (<42 mg/dL) in PNH patients (98.0%) were significantly higher than those in AA (27.8%; P<0.0001) and MDS (38.5%; P<0.0001) patients. In AA patients, white blood cell (WBC), absolute neutrophil, and platelet counts were significantly decreased in the group (n = 15) with low concentrations of serum Hp than in that (n = 39) with normal concentrations of it, and WBC counts were positively correlated with concentrations of serum Hp, suggesting that WBC counts may affect the concentrations. In MDS patients, hemoglobin concentrations and serum iron were significantly decreased and increased, respectively, in the group (n = 20) with low concentrations of serum Hp than in that (n = 32) with normal concentrations of it, and the values of serum iron were inversely correlated with concentrations of serum Hp, suggesting that ineffective erythropoiesis may affect the concentrations. Several AA and MDS patients with low concentrations of serum Hp had Coombs-negative autoimmune hemolytic anemia determined by immunoradiometric assay. In conclusion, several factors in conjunction with pathophysiology contribute to decrease of serum Hp in BMF.

Original languageEnglish
Pages (from-to)602-610
Number of pages9
JournalInternational journal of hematology
Volume91
Issue number4
DOIs
Publication statusPublished - 2010 May

Keywords

  • Acquired bone marrow failure syndromes
  • Complement-mediated hemolysis
  • Coombs-negative autoimmune hemolytic anemia
  • Ineffective hematopoiesis
  • Serum haptoglobin

ASJC Scopus subject areas

  • Hematology

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