Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Hiroaki Nozawa; Eri Oda; Kazuki Nakao; Masahiko Ishihara; Seiji Ueda; Taeko Yokochi; Kouetsu Ogasawata; Yoko Nakatsuru; Seiichito Shimizu; Yoshikazu Ohira; Kyoji Hioki; Shinichi Aizawa; Takatoshi Ishikawa; Motoya Katsuki; Tetsuichiro Muto; Tadatsugu Taniguchi; Nobuyuki Tanaka

doi:10.1101/gad.13.10.1240

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Hiroaki Nozawa, Eri Oda, Kazuki Nakao, Masahiko Ishihara, Seiji Ueda, Taeko Yokochi, Kouetsu Ogasawata, Yoko Nakatsuru, Seiichito Shimizu, Yoshikazu Ohira, Kyoji Hioki, Shinichi Aizawa, Takatoshi Ishikawa, Motoya Katsuki, Tetsuichiro Muto, Tadatsugu Taniguchi, Nobuyuki Tanaka

Research output: Contribution to journal › Article › peer-review

113 Citations (Scopus)

Abstract

The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.

Original language	English
Pages (from-to)	1240-1245
Number of pages	6
Journal	Genes and Development
Volume	13
Issue number	10
DOIs	https://doi.org/10.1101/gad.13.10.1240
Publication status	Published - 1999 May 15
Externally published	Yes

Keywords

IRF-1
Mutation frequency
Tumor susceptibility gene
c-Ha-ras
p53

ASJC Scopus subject areas

Genetics
Developmental Biology

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Nozawa, H., Oda, E., Nakao, K., Ishihara, M., Ueda, S., Yokochi, T., Ogasawata, K., Nakatsuru, Y., Shimizu, S., Ohira, Y., Hioki, K., Aizawa, S., Ishikawa, T., Katsuki, M., Muto, T., Taniguchi, T., & Tanaka, N. (1999). Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes and Development, 13(10), 1240-1245. https://doi.org/10.1101/gad.13.10.1240

Nozawa, H, Oda, E, Nakao, K, Ishihara, M, Ueda, S, Yokochi, T, Ogasawata, K, Nakatsuru, Y, Shimizu, S, Ohira, Y, Hioki, K, Aizawa, S, Ishikawa, T, Katsuki, M, Muto, T, Taniguchi, T & Tanaka, N 1999, 'Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53', Genes and Development, vol. 13, no. 10, pp. 1240-1245. https://doi.org/10.1101/gad.13.10.1240

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abstract = "The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.",

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AU - Ishihara, Masahiko

AU - Ueda, Seiji

AU - Yokochi, Taeko

AU - Ogasawata, Kouetsu

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AU - Shimizu, Seiichito

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AU - Hioki, Kyoji

AU - Aizawa, Shinichi

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AU - Katsuki, Motoya

AU - Muto, Tetsuichiro

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AU - Tanaka, Nobuyuki

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KW - Tumor susceptibility gene

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KW - p53

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Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Abstract

Keywords

ASJC Scopus subject areas

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