Abstract
The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.
Original language | English |
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Pages (from-to) | 1240-1245 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 13 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1999 May 15 |
Externally published | Yes |
Keywords
- IRF-1
- Mutation frequency
- Tumor susceptibility gene
- c-Ha-ras
- p53
ASJC Scopus subject areas
- Genetics
- Developmental Biology