Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Hiroaki Nozawa; Eri Oda; Kazuki Nakao; Masahiko Ishihara; Seiji Ueda; Taeko Yokochi; Kouetsu Ogasawata; Yoko Nakatsuru; Seiichito Shimizu; Yoshikazu Ohira; Kyoji Hioki; Shinichi Aizawa; Takatoshi Ishikawa; Motoya Katsuki; Tetsuichiro Muto; Tadatsugu Taniguchi; Nobuyuki Tanaka

doi:10.1101/gad.13.10.1240

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Hiroaki Nozawa, Eri Oda, Kazuki Nakao, Masahiko Ishihara, Seiji Ueda, Taeko Yokochi, Kouetsu Ogasawata, Yoko Nakatsuru, Seiichito Shimizu, Yoshikazu Ohira, Kyoji Hioki, Shinichi Aizawa, Takatoshi Ishikawa, Motoya Katsuki, Tetsuichiro Muto, Tadatsugu Taniguchi, Nobuyuki Tanaka

Division of Aging Science

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.

Original language	English
Pages (from-to)	1240-1245
Number of pages	6
Journal	Genes and Development
Volume	13
Issue number	10
DOIs	https://doi.org/10.1101/gad.13.10.1240
Publication status	Published - 1999 May 15

Keywords

IRF-1
Mutation frequency
Tumor susceptibility gene
c-Ha-ras
p53

ASJC Scopus subject areas

Genetics
Developmental Biology

Access to Document

10.1101/gad.13.10.1240

Fingerprint Dive into the research topics of 'Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53'. Together they form a unique fingerprint.

Cite this

Nozawa, H., Oda, E., Nakao, K., Ishihara, M., Ueda, S., Yokochi, T., Ogasawata, K., Nakatsuru, Y., Shimizu, S., Ohira, Y., Hioki, K., Aizawa, S., Ishikawa, T., Katsuki, M., Muto, T., Taniguchi, T., & Tanaka, N. (1999). Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. Genes and Development, 13(10), 1240-1245. https://doi.org/10.1101/gad.13.10.1240

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. / Nozawa, Hiroaki; Oda, Eri; Nakao, Kazuki; Ishihara, Masahiko; Ueda, Seiji; Yokochi, Taeko; Ogasawata, Kouetsu; Nakatsuru, Yoko; Shimizu, Seiichito; Ohira, Yoshikazu; Hioki, Kyoji; Aizawa, Shinichi; Ishikawa, Takatoshi; Katsuki, Motoya; Muto, Tetsuichiro; Taniguchi, Tadatsugu; Tanaka, Nobuyuki.

In: Genes and Development, Vol. 13, No. 10, 15.05.1999, p. 1240-1245.

Research output: Contribution to journal › Article › peer-review

Nozawa, H, Oda, E, Nakao, K, Ishihara, M, Ueda, S, Yokochi, T, Ogasawata, K, Nakatsuru, Y, Shimizu, S, Ohira, Y, Hioki, K, Aizawa, S, Ishikawa, T, Katsuki, M, Muto, T, Taniguchi, T & Tanaka, N 1999, 'Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53', Genes and Development, vol. 13, no. 10, pp. 1240-1245. https://doi.org/10.1101/gad.13.10.1240

Nozawa, Hiroaki ; Oda, Eri ; Nakao, Kazuki ; Ishihara, Masahiko ; Ueda, Seiji ; Yokochi, Taeko ; Ogasawata, Kouetsu ; Nakatsuru, Yoko ; Shimizu, Seiichito ; Ohira, Yoshikazu ; Hioki, Kyoji ; Aizawa, Shinichi ; Ishikawa, Takatoshi ; Katsuki, Motoya ; Muto, Tetsuichiro ; Taniguchi, Tadatsugu ; Tanaka, Nobuyuki. / Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53. In: Genes and Development. 1999 ; Vol. 13, No. 10. pp. 1240-1245.

@article{b2fcc7a4b40445d193c656d45ecad9a9,

title = "Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53",

abstract = "The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.",

keywords = "IRF-1, Mutation frequency, Tumor susceptibility gene, c-Ha-ras, p53",

author = "Hiroaki Nozawa and Eri Oda and Kazuki Nakao and Masahiko Ishihara and Seiji Ueda and Taeko Yokochi and Kouetsu Ogasawata and Yoko Nakatsuru and Seiichito Shimizu and Yoshikazu Ohira and Kyoji Hioki and Shinichi Aizawa and Takatoshi Ishikawa and Motoya Katsuki and Tetsuichiro Muto and Tadatsugu Taniguchi and Nobuyuki Tanaka",

year = "1999",

month = may,

day = "15",

doi = "10.1101/gad.13.10.1240",

language = "English",

volume = "13",

pages = "1240--1245",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "10",

}

TY - JOUR

T1 - Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

AU - Nozawa, Hiroaki

AU - Oda, Eri

AU - Nakao, Kazuki

AU - Ishihara, Masahiko

AU - Ueda, Seiji

AU - Yokochi, Taeko

AU - Ogasawata, Kouetsu

AU - Nakatsuru, Yoko

AU - Shimizu, Seiichito

AU - Ohira, Yoshikazu

AU - Hioki, Kyoji

AU - Aizawa, Shinichi

AU - Ishikawa, Takatoshi

AU - Katsuki, Motoya

AU - Muto, Tetsuichiro

AU - Taniguchi, Tadatsugu

AU - Tanaka, Nobuyuki

PY - 1999/5/15

Y1 - 1999/5/15

N2 - The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.

AB - The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.

KW - IRF-1

KW - Mutation frequency

KW - Tumor susceptibility gene

KW - c-Ha-ras

KW - p53

UR - http://www.scopus.com/inward/record.url?scp=0033563225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033563225&partnerID=8YFLogxK

U2 - 10.1101/gad.13.10.1240

DO - 10.1101/gad.13.10.1240

M3 - Article

C2 - 10346812

AN - SCOPUS:0033563225

VL - 13

SP - 1240

EP - 1245

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 10

ER -