Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

Hiroaki Nozawa, Eri Oda, Kazuki Nakao, Masahiko Ishihara, Seiji Ueda, Taeko Yokochi, Kouetsu Ogasawata, Yoko Nakatsuru, Seiichito Shimizu, Yoshikazu Ohira, Kyoji Hioki, Shinichi Aizawa, Takatoshi Ishikawa, Motoya Katsuki, Tetsuichiro Muto, Tadatsugu Taniguchi, Nobuyuki Tanaka

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

The transcription factor IRF-1 has been implicated in tumor suppression: IRF-1 suppresses cell transformation and mediates apoptosis in vitro. Here we show that the loss of IRF-1 alleles per se has no effect on spontaneous tumor development in the mouse but dramatically exacerbates previous tumor predispositions caused by the c-Ha-ras transgene or by nullizygosity for p53. Grossly altered tumor spectrum, as compared to p53-null mice, was also observed in mice lacking both IRF-1 and p53, and cells from these mice show significantly higher mutation rate. Our results suggest that IRF-1 is a new member of the tumor susceptibility genes.

Original languageEnglish
Pages (from-to)1240-1245
Number of pages6
JournalGenes and Development
Volume13
Issue number10
DOIs
Publication statusPublished - 1999 May 15

Keywords

  • IRF-1
  • Mutation frequency
  • Tumor susceptibility gene
  • c-Ha-ras
  • p53

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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