Loss of RegI in conjunction with gastrin deficiency in mice facilitates efficient gastric ulcer healing but is dispensable for hyperplasia and tumourigenesis

Anthony J. Peterson, Nhung Nguyen, Hiroshi Okamoto, Andrew S. Giraud, Ian R. van Driel, Louise M. Judd

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

RegI (Regenerating islet derived-1) was originally characterized as a growth factor involved in pancreatic islet cell regeneration. It is also considered a gastrointestinal mitogen as its expression is increased during pathologies involving aberrant cell proliferation that can lead to neoplasia. However, the absolute requirement for RegI to directly stimulate gastric mucosal cell proliferation in vivo requires further investigation. We used RegI-deficient mice to determine the requirement for RegI in normal gastric mucosal development, wound healing, hyperplasia and tumourigenesis. We found that epithelial repair of acetic acid ulcers in compound mutant RegI/gastrin-deficient mice was significantly reduced compared to wild type, RegI-deficient or gastrin-deficient mice. In contrast, RegI was dispensable for normal gastric mucosal development, hyperplasia in HKβ-deficient mice and tumourigenesis in gp130F/F mice. Although RegI was not required for proliferation in these pathological models, expression of multiple Reg family members were increased during gp130F/F tumourigenesis. Interestingly, loss of RegI in gp130F/F mice resulted in decreased expression of other Reg family members. Our results indicate that RegI and gastrin may synergistically regulate gastric mucosal proliferation during certain pathological settings like wound healing while gastric epithelial proliferation in other pathologies may require coordinated expression of multiple Reg genes.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalRegulatory Peptides
Volume160
Issue number1-3
DOIs
Publication statusPublished - 2010 Feb 25

Keywords

  • Gastric cancer
  • Reg family
  • Regeneration
  • STAT3
  • Ulceration

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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