Loss of heterozygosity of nucleotide excision repair factors in sporadic oral squamous cell carcinoma using microdissected tissue

Hitoshi Miyashita, Shiro Mori, Naoka Tanda, Kentaro Nakayama, Atsuko Kanzaki, Atushi Sato, Hidehiro Morikawa, Katutoshi Motegi, Yuji Takebayashi, Manabu Fukumoto

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The deficiencies of nucleotide excision repair (NER) factors are involved in rare genetic diseases such as xeroderma pigmentosum (XP) with increased risk of developing cancer on sun-exposed areas of the skin. However, the abnormality of NER factors in human sporadic carcinoma remains unclear. Loss of heterozygosity (LOH) analysis, using the microdissected tissues, for the XPA, XPB, XPC, XPD, XPE, XPF, XPG and.the transcription-coupled repair factor, Cockayne syndrome B (CSB) revealed that NER factors were abnormal in 30.0% (3/10 cases) of oral squamous cell carcinomas. Furthermore, 10.0% of oral carcinomas exhibited LOH for NER factors without LOH for tumor suppressor genes such as p53, FHIT, APC, BRCA1, BRCA2 and DCC. These observations raise the possibility that alterations of NER factors may be involved in carcinogenesis in human oral squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1133-1138
Number of pages6
JournalOncology reports
Volume8
Issue number5
Publication statusPublished - 2001 Jan 1

Keywords

  • Carcinogcnesis
  • Genome
  • Loss of heterozygosity
  • Nuclcotide excision repair
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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