Loss of Heterozygosity at 11p15 in Malignant Glioma

Yukihiko Sonoda, Masayoshi Iizuka, Jun Yasuda, Reiko Makino, Takao Sekiya, Yukihiko Sonoda, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Deletions of loci on chromosome lip have been found frequently in several malignant tumors including gliomas, suggesting the presence of tumor suppressor genes. We analyzed 38 gliomas [26 malignant gliomas (grades HI and IV) and 12 less malignant gliomas (grades I and II)] for loss of heterozygosity using microsatellite sequences on lip as polymorphic markers. Loss of heterozygosity was found in 8 of 26 malignant gliomas (31%) but not in the less malignant gliomas. In the region with loss of heterozygosity, loci on Up15.5-pter were commonly deleted. Our results suggest that a putative tumor suppressor gene involved in malignant progression of gliomas is located in an approximately 21-cM region on 11p15.5-pter.

Original languageEnglish
Pages (from-to)2166-2168
Number of pages3
JournalCancer Research
Issue number10
Publication statusPublished - 1995 May 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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