Loss of Heterozygosity at 11p15 in Malignant Glioma

Yukihiko Sonoda, Masayoshi Iizuka, Jun Yasuda, Reiko Makino, Takao Sekiya, Yukihiko Sonoda, Takamasa Kayama, Takashi Yoshimoto, Tetsuya Ono

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45 Citations (Scopus)

Abstract

Deletions of loci on chromosome lip have been found frequently in several malignant tumors including gliomas, suggesting the presence of tumor suppressor genes. We analyzed 38 gliomas [26 malignant gliomas (grades HI and IV) and 12 less malignant gliomas (grades I and II)] for loss of heterozygosity using microsatellite sequences on lip as polymorphic markers. Loss of heterozygosity was found in 8 of 26 malignant gliomas (31%) but not in the less malignant gliomas. In the region with loss of heterozygosity, loci on Up15.5-pter were commonly deleted. Our results suggest that a putative tumor suppressor gene involved in malignant progression of gliomas is located in an approximately 21-cM region on 11p15.5-pter.

Original languageEnglish
Pages (from-to)2166-2168
Number of pages3
JournalCancer Research
Volume55
Issue number10
Publication statusPublished - 1995 May 15

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Sonoda, Y., Iizuka, M., Yasuda, J., Makino, R., Sekiya, T., Sonoda, Y., Kayama, T., Yoshimoto, T., & Ono, T. (1995). Loss of Heterozygosity at 11p15 in Malignant Glioma. Cancer Research, 55(10), 2166-2168.