Loss of genes on chromosome 22 in medullary thyroid carcinoma and pheochromocytoma

Shin Ichiro Takai, Hideo Tateishi, Isamu Nishisho, Tetsuro Miki, Kazuyoshi Motomura, Akira Miyauchi, Makoto Kato, Tatsuro Ikeuchi, Kohtaro Yamamoto, Makoto Okazaki, Masayuki Yamamoto, Tasuku Honjo, Yuichi Kumahara, Takesada Mori

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Using polymorphic DNA markers, we compared the constitutional and tumor genotypes of patients with multiple endocrine neoplasia type 2A (MEN2 A). We found loss of constitutional heterozygosity at the D22S9 locus in one out of 9 medullary thyroid carcinomas (MTCs). No loss of heterozygosity was detected at 12 other loci in any of the MTCs tested. Loss of heterozygosity at D22S9 and/or D22S1 was also demonstrated in 2 out of 5 pheochromocytomas tested. These results suggest that loss or mutation of a gene on chromosome 22 may play an important role in tumorigenesis in MEN2A.

Original languageEnglish
Pages (from-to)894-898
Number of pages5
JournalJapanese Journal of Cancer Research GANN
Volume78
Issue number9
Publication statusPublished - 1987
Externally publishedYes

Keywords

  • Chromosome 22
  • Loss of heterozygosity
  • Medullary thyroid carcinoma
  • Multiple endocrine neoplasia type 2A
  • Pheochromocytoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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