Loss of awareness of hyposmia is associated with mild cognitive impairment in Parkinson's disease

Iori Kawasaki, Toru Baba, Atsushi Takeda, Etsuro Mori

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Background: Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we investigated the relationship between the degree of hyposmia self-awareness and the cognitive status of non-demented PD patients. Methods: Thirty-one non-demented patients with PD and 20 healthy controls (HC) were assessed via a self-reported olfactory questionnaire and an odor identification test. PD patients were sub-classified as having mild cognitive impairment (PD-MCI) or as cognitively normal (PD-CN) (according to the current PD-MCI criteria). We compared the degree of hyposmia self-awareness between the PD-MCI and PD-CN groups. Results: The PD-MCI group scored the lowest on the odor identification test among all groups, whereas PD-MCI patients tended to rate their olfactory function higher on the self-reported olfactory questionnaire than PD-CN patients. Differences in the scores of subjective and objective olfactory measures between the PD-MCI and PD-CN groups were significant (p = 0.0069). Conclusions: The loss of awareness of hyposmia is closely associated with mild cognitive impairment (MCI) in PD patients.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
JournalParkinsonism and Related Disorders
Volume22
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Awareness
  • Cognitive impairment
  • Olfaction
  • Parkinson's disease
  • Parkinson's disease with mild cognitive impairment

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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