TY - JOUR
T1 - Loss of awareness of hyposmia is associated with mild cognitive impairment in Parkinson's disease
AU - Kawasaki, Iori
AU - Baba, Toru
AU - Takeda, Atsushi
AU - Mori, Etsuro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research (B) ( 24390278 to E. M. ) and a Grant-in-Aid for Scientific Research for Young Scientists (B) ( 26860657 to T. B. ) from the Ministry of Education, Science and Technology . This work was also supported by a Grant-in-Aid for Scientific Research (T. B.) from the Japan Foundation for Neuroscience and Mental Health .
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we investigated the relationship between the degree of hyposmia self-awareness and the cognitive status of non-demented PD patients. Methods: Thirty-one non-demented patients with PD and 20 healthy controls (HC) were assessed via a self-reported olfactory questionnaire and an odor identification test. PD patients were sub-classified as having mild cognitive impairment (PD-MCI) or as cognitively normal (PD-CN) (according to the current PD-MCI criteria). We compared the degree of hyposmia self-awareness between the PD-MCI and PD-CN groups. Results: The PD-MCI group scored the lowest on the odor identification test among all groups, whereas PD-MCI patients tended to rate their olfactory function higher on the self-reported olfactory questionnaire than PD-CN patients. Differences in the scores of subjective and objective olfactory measures between the PD-MCI and PD-CN groups were significant (p = 0.0069). Conclusions: The loss of awareness of hyposmia is closely associated with mild cognitive impairment (MCI) in PD patients.
AB - Background: Hyposmia is a common non-motor symptom in Parkinson's disease (PD). However, patients with PD are sometimes unaware of their olfactory dysfunction, resulting in an under-diagnosis of this symptom. To determine whether the loss of awareness of hyposmia results from cognitive impairment in patients with PD, we investigated the relationship between the degree of hyposmia self-awareness and the cognitive status of non-demented PD patients. Methods: Thirty-one non-demented patients with PD and 20 healthy controls (HC) were assessed via a self-reported olfactory questionnaire and an odor identification test. PD patients were sub-classified as having mild cognitive impairment (PD-MCI) or as cognitively normal (PD-CN) (according to the current PD-MCI criteria). We compared the degree of hyposmia self-awareness between the PD-MCI and PD-CN groups. Results: The PD-MCI group scored the lowest on the odor identification test among all groups, whereas PD-MCI patients tended to rate their olfactory function higher on the self-reported olfactory questionnaire than PD-CN patients. Differences in the scores of subjective and objective olfactory measures between the PD-MCI and PD-CN groups were significant (p = 0.0069). Conclusions: The loss of awareness of hyposmia is closely associated with mild cognitive impairment (MCI) in PD patients.
KW - Awareness
KW - Cognitive impairment
KW - Olfaction
KW - Parkinson's disease
KW - Parkinson's disease with mild cognitive impairment
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U2 - 10.1016/j.parkreldis.2015.11.015
DO - 10.1016/j.parkreldis.2015.11.015
M3 - Article
C2 - 26639980
AN - SCOPUS:84951868067
VL - 22
SP - 74
EP - 79
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
SN - 1353-8020
ER -