Loss of alleles at loci on chromosome 13 in human primary gastric cancers

Kazuyoshi Motomura, Isamu Nishisho, Sin ichiro Takai, Hideo Tateishi, Makoto Okazaki, Masayuki Yamamoto, Tetsuro Miki, Tasuku Honjo, Takesada Mori

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

Mitotic events leading to the loss of the normal allele corresponding to a mutated gene are important for tumorigenesis in rare heritable tumors such as retinoblastoma and Wilms tumor. As reported for both colorectal and breast cancers, some common tumors seem to develop because of the same mitotic events. We examined constitutional and tumor genotypes defined by polymorphic DNA clones in 36 patients with gastric cancer. In 14 cases, constitutional heterozygosity at loci on chromosome 13 had been lost. Loss of alleles was also detected at a locus on chromosome 18 in two cases and at a locus on chromosome 17 in one case. The frequent loss of alleles at loci on chromosome 13 (41%) suggests that elimination of genes on this chromosome may be of importance in the tumorigenesis of human primary gastric cancers.

Original languageEnglish
Pages (from-to)180-184
Number of pages5
JournalGenomics
Volume2
Issue number2
DOIs
Publication statusPublished - 1988 Feb

ASJC Scopus subject areas

  • Genetics

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