Longitudinal changes in 18F-THK5351 positron emission tomography in corticobasal syndrome

M. Ezura, A. Kikuchi, A. Ishiki, N. Okamura, T. Hasegawa, R. Harada, S. Watanuki, Y. Funaki, K. Hiraoka, T. Baba, N. Sugeno, R. Oshima, S. Yoshida, J. Kobayashi, M. Kobayashi, O. Tano, I. Nakashima, S. Mugikura, R. Iwata, Y. TakiK. Furukawa, H. Arai, S. Furumoto, M. Tashiro, K. Yanai, Y. Kudo, A. Takeda, M. Aoki

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background and purpose: Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, 18F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease-related pathology in the brains of patients with CBS using positron emission tomography with 18F-THK5351. Methods: Baseline and 1-year follow-up imaging were acquired using magnetic resonance imaging and positron emission tomography with 18F-THK5351 in 10 subjects: five patients with CBS and five age-matched normal controls (NCs). Results: The 1-year follow-up scan images revealed that 18F-THK5351 retention had significantly increased in the superior parietal gyrus of the patients with CBS compared with the NCs. The median increases in 18F-THK5351 accumulation in the patients with CBS were 6.53% in the superior parietal gyrus, 4.34% in the precentral gyrus and 4.33% in the postcentral gyrus. In contrast, there was no significant increase in the regional 18F-THK5351 retention in the NCs. Conclusions: Longitudinal increases in 18F-THK5351 binding can be detected over a short interval in the cortical sites of patients with CBS. A monoamine oxidase B binding radiotracer could be useful in monitoring the progression of astrogliosis in CBS.

Original languageEnglish
Pages (from-to)1205-1211
Number of pages7
JournalEuropean Journal of Neurology
Volume26
Issue number9
DOIs
Publication statusPublished - 2019

Keywords

  • F-THK5351
  • PET
  • corticobasal syndrome
  • longitudinal change
  • monoamine oxidase B
  • tau deposits

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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