Long-term treatment with perindopril ameliorates dobutamine-induced myocardial ischemia in patients with coronary artery disease

Tsuyoshi Morishita, Masato Tsutsui, Hiroaki Shimokawa, Hiromi Tasaki, Osamu Suda, Kengo Kobayashi, Masataka Horiuchi, Haruhito Okuda, Yuki Tsuda, Nobuyuki Yanagihara, Yasuhide Nakashima

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23 Citations (Scopus)

Abstract

The present study was designed to examine whether long-term blockade of angiotensin-converting enzyme (ACE) with perindopril ameliorates dobutamine-induced myocardial ischemia in patients with coronary artery disease (CAD). Twelve patients with proven CAD were randomly divided in two groups; one group received perindopril (8 mg/day, p.o.) for 3 months and another group served as a control. To evaluate anti-ischemic effects of perindopril, dobutamine stress echocardiography was performed before and 3 months after the treatment in a double-blind manner. Long-term treatment with perindopril significantly ameliorated the dobutamine-induced myocardial ischemia, as evaluated by time to the onset of symptoms, magnitude of electrocardiographic ST-segment changes, and left ventricular wall motion score (all P<0.05). The treatment significantly decreased serum ACE activities (P<0.01) and increased plasma bradykinin concentrations (P<0.05). The extent of reduction of left ventricular wall motion score by perindopril was closely correlated with that of inhibition of serum ACE activities (P<0.01) and with that of increase in plasma bradykinin concentrations (P<0.05). By contrast, no such beneficial changes were noted in the control group. These results provide the first evidence that long-term treatment with perindopril exerts anti-ischemic effects on the myocardial ischemia induced by increased myocardial oxygen demand in patients with CAD.

Original languageEnglish
Pages (from-to)100-107
Number of pages8
JournalJapanese Journal of Pharmacology
Volume88
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • Angiotensin-converting enzyme inhibitor
  • Coronary artery disease
  • Dobutamine stress echocardiography
  • Myocardial ischemia
  • Perindopril

ASJC Scopus subject areas

  • Pharmacology

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