Long-term right ventricular volume overload increases myocardial fluorodeoxyglucose uptake in the interventricular septum in patients with atrial septal defect

Hiroki Otani, Yutaka Kagaya, Yuriko Yamane, Masanobu Chida, Kenta Ito, Shigeto Namiuchi, Nobuyuki Shiba, Yoshito Koseki, Mototsugu Ninomiya, Jun Ikeda, Haruo Saito, Shin Maruoka, Takehiko Fujiwara, Tatsuo Ido, Nobumasa Ishide, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Background - Several studies have shown that long-term right ventricular (RV) overload in animal models alters myocardial energy substrate metabolism. However, whether long-term RV volume overload alters this metabolism in the human is unclear. Methods and Results - We performed positron emission tomography with [18F]fluorodeoxyglucose (FDG) and single-photon emission tomography (SPECT) with [201Tl] (Tl) and [123I]15-(p-iodophenyl)-3-R,S- methylpentadecanoic acid (BMIPP) in 11 patients with atrial septal defect (ASD) and 11 control subjects. In the FDG study, we calculated myocardial metabolic rate of glucose (MMR) in interventricular septum (IVS) and left ventricular (LV) free wall. MMR was significantly increased in IVS compared with LV free wall in the ASD patients (420±35 versus 333±32 mol · kg-1 · min-1; P<0.05) but not in the control group (347±27 versus 357±25 mol · kg-1 · min-1). In both ASD and control groups, SPECT count was not significantly different between IVS and LV free wall in Tl (ASD, 160±1 versus 177±12; control, 141±12 versus 157±14 counts per 15 minutes) and BMIPP studies (ASD, 203±14 versus 212±18; control, 162±16 versus 176±16 counts per 15 minutes). MMR in the IVS/LV free wall ratio in the ASD group significantly correlated with indices related to RV volume overload. Conclusions - Given the assumption that long-term RV volume overload did not affect the lumped constant, the present study suggests that, unlike myocardial perfusion or fatty acid analogue uptake, myocardial glucose utilization in IVS relative to LV free wall is increased in relation to long- term RV volume overload in patients with ASD.

Original languageEnglish
Pages (from-to)1686-1692
Number of pages7
JournalCirculation
Volume101
Issue number14
DOIs
Publication statusPublished - 2000 Apr 11

Keywords

  • Glucose
  • Heart septal defects
  • Metabolism
  • Nuclear medicine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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