Long-term results of radiochemotherapy for solitary lymph node metastasis after curative resection of esophageal cancer

Keiichi Jingu, Hisanori Ariga, Kenji Nemoto, Kakutaro Narazaki, Rei Umezawa, Ken Takeda, Masashi Koto, Toshiyuki Sugawara, Masaki Kubozono, Goh Miyata, Ko Onodera, Shogo Yamada

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Purpose: To evaluate the long-term efficacy and toxicity of definitive radiochemotherapy for solitary lymph node metastasis after curative surgery of esophageal cancer. Methods and Materials: We performed a retrospective review of 35 patients who underwent definitive radiochemotherapy at Tohoku University Hospital between 2000 and 2009 for solitary lymph node metastasis after curative esophagectomy with lymph node dissection for esophageal cancer. Radiotherapy doses ranged from 60 to 66 Gy (median, 60 Gy). Concurrent chemotherapy was platinum based in all patients. The endpoints of the present study were overall survival, cause-specific survival, progression-free survival, irradiated-field control, overall tumor response, and prognostic factors. Results: The median observation period for survivors was 70.0 months. The 5-year overall survival was 39.2% (median survival, 39.0 months). The 5-year cause-specific survival, progression-free survival, and irradiated-field control were 43.3%, 31.0% and 59.9%, respectively. Metastatic lesion, size of the metastatic lymph node, and performance status before radiochemotherapy were significantly correlated with prognosis. Complete response and partial response were observed in 22.9% and 57.1% of the patients, respectively. There was no Grade 3 or higher adverse effect based on theCommon Terminology Criteria for Adverse Events (CTCAE v3.0) in the late phase. Conclusions: Based on our study findings, approximately 40% of patients with solitary lymph node metastasis after curative resection for esophageal cancer have a chance of long-term survival with definitive radiochemotherapy.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume83
Issue number1
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • Long-term results
  • Postoperative recurrent esophageal cancer
  • Prognostic factor
  • Radiochemotherapy
  • Solitary lymph node metastasis

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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