Long-term outcomes of hypofractionated stereotactic radiotherapy for the treatment of perioptic nonfunctioning pituitary adenomas

Aiko Hata, Masaya Oda, Takahiro Ono, Akira Suzuki, Noriaki Hanyu, Masataka Takahashi, Toshio Sasajima, Manabu Hashimoto, Taizen Nakase, Hiroaki Shimizu

Research output: Contribution to journalArticlepeer-review


The efficacy of stereotactic radiotherapy (SRT) has been well established for postoperative residual and recurrent nonfunctioning pituitary adenomas (NFPAs). However, the risk of visual impairment due to SRT for lesions adjacent to the optic pathways remains a topic of debate. Herein, we evaluated the long-term clinical outcomes of hypofractionated stereotactic radiotherapy (HFSRT) for perioptic NFPAs. From December 2002 to November 2015, 32 patients (18 males and 14 females; median age 63 years; range, 36–83 years) with residual or recurrent NFPAs abutting or displacing the optic nerve and/or chiasm (ONC) were treated with HFSRT. The median marginal dose was 31.3 Gy (range, 17.2–39.6) in 8 fractions (range, 6–15). Magnetic resonance imaging (MRI) and visual and hormonal examinations were performed before and after HFSRT. The median follow-up period was 99.5 months (range, 9–191). According to MRI findings at the last follow-up, the tumor size had decreased in 28 (88%) of 32 patients, was unchanged in 3 (9%), and had increased in 1 (3%). The successful tumor size control rate was 97%. Visual functions remained unchanged in 19 (60%) out of 32 patients, improved in 11 (34%), and deteriorated in 2 (6%). Two patients had deteriorated visual functions; no complications occurred because of the HFSRT. One patient developed hypopituitarism that required hormone replacement therapy. The result of this long-term follow-up study suggests that HFSRT is safe and effective for the treatment of NFPAs occur-ring adjacent to the ONC.

Original languageEnglish
Pages (from-to)404-413
Number of pages10
JournalNeurologia medico-chirurgica
Issue number7
Publication statusPublished - 2021
Externally publishedYes


  • Hypofractionated stereotactic radiotherapy
  • Long-term outcomes
  • Nonfunctioning pituitary adenomas
  • Optic chiasm
  • Optic nerve

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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