Long-term outcome of breast-conserving therapy for breast cancer

Akiko Shimauchi, Kenji Nemoto, Yoshihiro Ogawa, Yoshihisa Kakuto, Toru Sakayauchi, Yoshihiro Takai, Takanori Ishida, Noriaki Ohuchi, Hisashi Hirakawa, Michio Kimura, Takayuki Yamada, Shoki Takahashi, Shogo Yamada

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Purpose: We present a retrospective analysis of long-term therapeutic results for patients treated in our institution to evaluate the efficacy of breast-conserving therapy (BCT). Patients and Methods: The study population was 99 patients (102 breasts) with stage 0, I, and II breast cancer who underwent breast conservation therapy between April 1990 and November 1997. The entire breast was irradiated to a median dose of 50 Gy (range, 50-60 Gy) in 25-30 fractions. An additional 10 Gy in five fractions with 6-12 MeV electrons was given to 23 breasts (23%) with positive surgical margins. Results: The 5-/10-year overall survival, cause-specific survival, relapse-free rate, local recurrence, and regional recurrence rates were 94.6/93.3%, 95.7/94.5%, 88.2/77.5%, 4.2/8.5%, and 2.0/6.3%, respectively. In both uni- and multivariate analyses, age < 40 years was a significant prognostic factor for local recurrence. No severe morbidity was observed. Conclusion: The long-term clinical outcome of BCT for early breast carcinoma patients in our department was favorable. Patient age <40 was the most important factor associated with an increased risk of local recurrence in the ipsilateral breast.

Original languageEnglish
Pages (from-to)485-490
Number of pages6
JournalRadiation Medicine - Medical Imaging and Radiation Oncology
Volume23
Issue number7
Publication statusPublished - 2005 Nov

Keywords

  • Breast cancer
  • Breast-conserving therapy
  • Radiation therapy

ASJC Scopus subject areas

  • Radiation
  • Radiology Nuclear Medicine and imaging
  • Oncology

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