Long-term incidence and characteristics of intestinal failure in Crohn's disease: A multicenter study

Kazuhiro Watanabe, Iwao Sasaki, Kouhei Fukushima, Kitaro Futami, Hiroki Ikeuchi, Akira Sugita, Riichiro Nezu, Tsunekazu Mizushima, Shingo Kameoka, Masato Kusunoki, Kazuhiko Yoshioka, Yuji Funayama, Toshiaki Watanabe, Hisao Fujii, Mamoru Watanabe

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Background: The aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn's disease (CD). Methods: The present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected (n = 1,703). Those who developed IF were reviewed (n = 68), and the cumulative risk of IF was analyzed by the Kaplan-Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed (n = 33). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed. Results: The cumulative risk of IF after the initial surgery was 0.8 % (5 years), 3.6 % (10 years), 6.1 % (15 years), and 8.5 % (20 years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1 years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163 cm. Twelve IF patients (12 %) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1 % (3 years), 3.7 % (5 years), 6.5 % (7 years), and 8.9 % (10 years). Conclusion: The occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalJournal of gastroenterology
Volume49
Issue number2
DOIs
Publication statusPublished - 2014 Feb

Keywords

  • Crohn's disease
  • Home parenteral nutrition
  • Intestinal failure
  • Short bowel syndrome
  • Surgery

ASJC Scopus subject areas

  • Gastroenterology

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