Long-term follow-up study of bone mineral density in a patient with adult idiopathic Fanconi syndrome

Koichi Uchida, Shigekazu Yuasa, Norihiro Takahashi, Tetsuo Shoji, Hideyasu Kiyomoto, Hiroshi Fujioka, Mayuko Hashimoto, Yoko Fujita, Hirohide Matsuo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A 64-year-old woman complaining of severe lumbar pain was admitted to our hospital because of the finding of pre-existing mitral valve regurgitation on examination. Laboratory data revealed the proximal type of renal tubular acidosis, renal glucosuria, phosphaturia, generalized aminoaciduria and low-molecular-weight proteinuria. She did not have any cause of these tubular dysfunctions, and was diagnosed as adult idiopathic Fanconi syndrome. Dual energy X-ray absorptiometry (DEXA) revealed a reduction of bone mineral density in the lumbar spine to about 65% of the age-and gender-matched control value. Alkali agents (sodium citrate and potassium citrate), calcium lactate and 1α-hydroxyvitamin D3 were administered. Bone mineral density estimated with DEXA improved with a reduction of serum alkali phosphatase and disappearance of lumbar pain, and was restored to 82% of the age-and gender-matched control value after about 30 months of treatment. DEXA is useful for the long-term follow-up study of bone mineral density in a patient with Fanconi syndrome.

Original languageEnglish
Pages (from-to)178-182
Number of pages5
JournalJapanese Journal of Nephrology
Volume39
Issue number2
Publication statusPublished - 1997 Dec 1

Keywords

  • 1α-hydroxyvitamin D
  • Bone mineral density change
  • Dual energy X-ray absorptiometry
  • Fanconi syndrome
  • Osteomalacia
  • Renal tubular acidosis

ASJC Scopus subject areas

  • Nephrology

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