Long-term follow-up angiography of Moyamoya disease. Cases followed up from childhood to adolescence

A. Takahashi, S. Fujiwara, J. Suzuki

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22 Citations (Scopus)


We have reported the characteristic dynamic changes at the base of the brain in childhood Moyamoya disease in terms of follow-up angiography. So we have classified the angiographical findings of Moyamoya disease into six stages. However, there have been no report that proved these findings in long-term follow-up. On the other hand, these angiographical findings are mainly observed in children, we can seldom find out any changes in adults. We performed long-term follow up angiography in adult cases whose onset was in childhood to clarify the natural course of this disease and to understand the difference between the cases of children and adults. We can conclude that the angiographical dynamic changes were observed in almost all cases of childhood Moyamoya disease. These changes are consisted of decrease in basal moyamoya vessels and increase of other collateral circulation which are observed in bilateral carotid arterial systems. Therefore, unilateral moyamoya phenomenon especially in children must be distinguished from true Moyamoya disease by careful follow-up. In this study, high tendency of mental retardation was noted. It suggests that the prognosis of this disease in terms of mental activities is not so good as previously noted. Consequently, the patients which showed progressed stage and rich collateral circulation on angiography might be thought as Moyamoya disease whose lesion started in childhood even if the clinical onset of symptoms dislose in adult.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalNeurological Surgery
Issue number1
Publication statusPublished - 1986 Jan 1

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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