Long-term endoscopic remission in Crohn’s disease after allogeneic hematopoietic stem cell transplantation for diffuse large B cell lymphoma: case report and literature review

Yushi Inomata, Masatake Kuroha, Tomoyuki Handa, Yusuke Shimoyama, Rintaro Moroi, Hisashi Shiga, Yoichi Kakuta, Satoshi Ichikawa, Noriko Fukuhara, Yuichiro Sato, Taro Takahashi, Atsushi Masamune

Research output: Contribution to journalArticlepeer-review

Abstract

A 31-year-old man with Crohn’s disease in remission after 6-year treatment with infliximab developed nasopharyngeal diffuse large B cell lymphoma. Infliximab was discontinued, and complete remission was achieved following chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. However, the patient subsequently experienced severely symptomatic Crohn’s disease relapse. Therapy with adalimumab was initiated, and the patient attained remission. However, after 3 months, he suffered a recurrence of the lymphoma. Adalimumab was discontinued, and the patient received further chemotherapy (with rituximab, etoposide, cisplatin, methylprednisolone, and high-dose cytarabine) treatment and underwent allogeneic hematopoietic stem cell transplantation. Following the procedure, Crohn’s disease and lymphoma have remained in complete remission for 5 years. There are limited reports on Crohn’s disease remission after allogeneic hematopoietic stem cell transplantation. Therefore, we present this case report and a review of the existing literature on allogeneic stem cell transplantation for Crohn’s disease.

Original languageEnglish
Pages (from-to)1108-1114
Number of pages7
JournalClinical Journal of Gastroenterology
Volume14
Issue number4
DOIs
Publication statusPublished - 2021 Aug

Keywords

  • ASTIC trial
  • Adalimumab
  • Autologous hematopoietic stem cell transplantation
  • Infliximab
  • Umbilical cord blood transplantation

ASJC Scopus subject areas

  • Gastroenterology

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