Long-Term Efficacy of Partial Splenic Embolization in Children

Masaki Nio, Yutaka Hayashi, Nobuyuki Sano, Tomohiro Ishii, Hideyuki Sasaki, Ryoji Ohi

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Purpose: To elucidate the role of partial splenic embolization (PSE) procedures, long-term outcome was assessed in terms of the recurrence of thrombocytopenia. Methods: A retrospective study was performed after 41 PSE procedures in 36 patients for hypersplenism owing to portal hypertension. The underlying disease was biliary atresia in 32 patients, extrahepatic portal obstruction in 3, and idiopathic cirrhosis in 1. Results: The average volume embolized was 70.1%. The patients were followed up from 20 days to 182 months (average, 70.8 months). Five patients subsequently died, and 6 underwent liver transplantation. The causes of death or the reasons for liver transplantation were not related to hypersplenism. Eleven patients (30.6%) had recurrence of thrombocytopenia (<100,000/mm3). There was no significant difference in the volume embolized or platelet count before PSE between the patients with and without recurrence of thrombocytopenia. The peak value of platelet count after PSE was significantly lower in the patients with recurrence of thrombocytopenia (P = .0091). In 17 of 24 survivors without liver transplantation, platelet counts remained normal throughout the follow-up period. Conclusions: PSE is a safe and effective procedure. Hematologic indices improved in all 36 patients after PSE, and its long-term efficacy was shown in 70% of the survivors.

Original languageEnglish
Pages (from-to)1760-1762
Number of pages3
JournalJournal of Pediatric Surgery
Volume38
Issue number12
DOIs
Publication statusPublished - 2003 Dec

Keywords

  • Biliary atresia
  • Hypersplenism
  • Partial splenic embolization
  • Portal hypertension

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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