TY - JOUR
T1 - Long-Term Effects of Aldosterone on Kallikrein, Prostaglandin E2and Sodium in Rats
AU - Yasujima, Minoru
AU - Abe, Keishi
AU - Tanno, Masaya
AU - Kohzuki, Masahiro
AU - Kanazawa, Masayuki
AU - Omata, Ken
AU - Kasai, Yutaka
AU - Sato, Makito
AU - Takeuchi, Kazuhisa
AU - Itoh, Sadayoshi
AU - Yoshinaga, Kaoru
AU - Hiwatari, Masao
AU - Saito, Tsuyoshi
AU - Saso, Shunichi
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1987
Y1 - 1987
N2 - To assess the long-term effects of mineralocorticoids on the regulation of the synthesis or release of kallikrein and prostaglandin E2 in the renal kallikrein-kinin-prostaglandin E system, we studied the effects of chronic infusion of aldosterone (50 μg/kg/day) on urinary excretion of total and active kallikrein, and prostaglandin E2 for 10 days in conscious rats on regular intakes of sodium and on sodium loading with 1% NaCl as a drinking water. Chronic infusion of aldosterone induced a prompt and transient decrease in the ratio of sodium to potassium and a sustained increase in urinary prostaglandin E2 excretion in rats on regular diets, whereas urinary total and active kallikrein excretion did not increase significantly until the 4th day of aldosterone infusion. In rats loaded with sodium, aldosterone did not induce any changes in urinary total and active kallikrein excretion, whereas it induced similar changes in the ratio of sodium to potassium and urinary prostaglandin E2 excretion to those in rats on regular diets. Thus, the present results suggest that aldosterone might stimulate the synthesis or release of renal prostaglandin E2 independent of sodium balance. Furthermore, it is also suggested that aldosterone might stimulate the synthesis or release of kallikrein, at least partly, via the same pathway as sodium loading does.
AB - To assess the long-term effects of mineralocorticoids on the regulation of the synthesis or release of kallikrein and prostaglandin E2 in the renal kallikrein-kinin-prostaglandin E system, we studied the effects of chronic infusion of aldosterone (50 μg/kg/day) on urinary excretion of total and active kallikrein, and prostaglandin E2 for 10 days in conscious rats on regular intakes of sodium and on sodium loading with 1% NaCl as a drinking water. Chronic infusion of aldosterone induced a prompt and transient decrease in the ratio of sodium to potassium and a sustained increase in urinary prostaglandin E2 excretion in rats on regular diets, whereas urinary total and active kallikrein excretion did not increase significantly until the 4th day of aldosterone infusion. In rats loaded with sodium, aldosterone did not induce any changes in urinary total and active kallikrein excretion, whereas it induced similar changes in the ratio of sodium to potassium and urinary prostaglandin E2 excretion to those in rats on regular diets. Thus, the present results suggest that aldosterone might stimulate the synthesis or release of renal prostaglandin E2 independent of sodium balance. Furthermore, it is also suggested that aldosterone might stimulate the synthesis or release of kallikrein, at least partly, via the same pathway as sodium loading does.
KW - inactive kallikrein
KW - mineralocorticoids
KW - renal prostaglandin E
KW - sodium balance
KW - trypsin-activated kallikrein
UR - http://www.scopus.com/inward/record.url?scp=0023607395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023607395&partnerID=8YFLogxK
U2 - 10.1620/tjem.152.351
DO - 10.1620/tjem.152.351
M3 - Article
C2 - 3477885
AN - SCOPUS:0023607395
VL - 152
SP - 351
EP - 362
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 4
ER -