Long-term effect of low-frequency repetitive transcranial magnetic stimulation over the unaffected posterior parietal cortex in patients with unilateral spatial neglect

Keiichiro Shindo, Ken Sugiyama, Lu Huabao, Kazunori Nishijima, Takeo Kondo, Shin Ichi Izumi

Research output: Contribution to journalArticlepeer-review

83 Citations (Scopus)

Abstract

Objective: To explore long-term effects on unilateral spatial neglect of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected posterior parietal cortex. Design: Uncontrolled pilot study. Subjects: Two chronic-phase patients with left-sided unilateral spatial neglect from cerebral infarction. Methods: Six rTMS sessions were under taken for 2 weeks. Each session included 900 stimuli applied over P5 at an intensity of 95% motor thresholds and a frequency of 0.9 Hz. The Behavioural Inattention Test, either the Mini-Mental State Examination or the Revised Hasegawa Dementia Scale, Brunnstrom Recovery Stage, and Barthel Index were evaluated at 2-week intervals until 6 weeks after rTMS sessions. Single-photon emission computed tomography was performed 2 weeks before and after rTMS. Results: Behavioural Inattention Test scores improved remarkably, especially from 2 to 4 weeks after rTMS sessions. At 6 weeks, Behavioural Inattention Test scores still remained above pre-rTMS levels. Other clinical evaluations as well as single-photon emission computed tomography showed no significant change during the study. Conclusion: In this small pilot study, low-frequency rTMS over the unaffected posterior parietal cortex decreased unilateral spatial neglect for at least 6 weeks.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalJournal of Rehabilitation Medicine
Volume38
Issue number1
DOIs
Publication statusPublished - 2006 Jan

Keywords

  • Behavioural Inattention Test
  • Repetitive transcranial magnetic stimulation
  • Stroke
  • Unilateral spatial neglect

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

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