Long-term course of inflammatory bowel disease after the great east Japan earthquake

Teruko Miyazawa, Hisashi Shiga, Yoshitaka Kinouchi, Seiichi Takahashi, Gen Tominaga, Hiroki Takahashi, Sho Takagi, Nobuya Obana, Tatsuya Kikuchi, Shinya Omori, Yuichirou Sato, Shuichiro Takahashi, Ken Umemura, Katsuya Endo, Yoichi Kakuta, Masaki Matsuura, Tomoya Kimura, Masatake Kuroha, Tooru Shimosegawa

Research output: Contribution to journalArticle

Abstract

Background and Aim: This study analyzed inflammatory bowel disease activity for 2 years after the Great East Japan Earthquake. Methods: We compared the relapse rates of patients with ulcerative colitis or Crohn’s disease 1 and 2 years after the earthquake with rates immediately after the earthquake. To evaluate continuous disease courses, we also performed multivariate time-to-event analyses from the time of the earthquake to the onset of additional treatments. Results: Of 903 patients with ulcerative colitis or Crohn’s disease in our previous study, we could evaluate 2-year courses in 677 patients (394 ulcerative colitis and 283 Crohn’s disease). Compared with the relapse rates of ulcerative colitis and Crohn’s disease immediately after the earthquake (15.8% and 7.0%, respectively), those in the corresponding periods in 2012 (2.5% and 1.1%, respectively) and 2013 (2.3% and 2.5%, respectively) significantly decreased. There were 226 patients who required additional treatments after the earthquake. Multivariate time-to-event analyses revealed that only patients who had experienced the death of family members or friends were likely to need additional treatments (hazard ratio = 1.77, 95% confidence interval = 1.25–2.47). No other factors had a significant influence. Conclusions: The relapse rates 1 and 2 years after the earthquake significantly decreased. The factors that influenced long-term relapse were different from those that influenced short-term relapse.

Original languageEnglish
Pages (from-to)1956-1960
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume33
Issue number12
DOIs
Publication statusPublished - 2018 Dec

Keywords

  • Crohn’s disease
  • Inflammatory bowel disease
  • Ulcerative colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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