TY - JOUR
T1 - Long-standing high-transport membrane as a risk factor for EPS development after PD withdrawal
T2 - An analysis based on changes in peritoneal function during and after CAPD withdrawal
AU - Nakayama, Masaaki
AU - Ikeda, Masato
AU - Katoh, Naohiko
AU - Hayakawa, Hiroshi
AU - Numata, Miwako
AU - Otsuka, Yasushi
AU - Yamamoto, Ryo
AU - Yamamoto, Hiroyasu
AU - Yokoyama, Keitaro
AU - Kubo, Hitoshi
AU - Kawaguchi, Yoshindo
AU - Hosoya, Tatsuo
PY - 2002
Y1 - 2002
N2 - The pathophysiology of encapsulating peritoneal sclerosis (EPS) that develops after withdrawal from long-standing dependence on CAPD remains unclear. The aim of this study was to clarify the risk factors for EPS as expressed in the peritoneal function. Fourteen patients who had shifted to standard hemodialysis after long-term CAPD (average, 105 months) were studied : 3 developed EPS after PD withdrawal while 11 did not. Analysis of the data obtained from the peritoneal equilibration test (PET) revealed that : (1) the dialysate/plasma creatinine ratio (D/Pcr) was significantly higher in the EPS group than in the non-EPS group during the course of PD as well as after PD withdrawal ; and (2) eight patients, including the 3 with EPS, were classified as being in a high-transport membrane state (HTS) at PD withdrawal. The duration of HTS during PD was longer in those patients with EPS. During the periods after PD withdrawal, none of these EPS patients recovered from HTS, whereas 4 of the 5 non-EPS patients did. These data suggest that long-standing HTS during the course of PD as well as post-withdrawal, may be risk factors for EPS development. For this reason, it is indicated that PET has clinical relevance in examining sequential changes in peritoneal function and in detecting those patients at risk of EPS.
AB - The pathophysiology of encapsulating peritoneal sclerosis (EPS) that develops after withdrawal from long-standing dependence on CAPD remains unclear. The aim of this study was to clarify the risk factors for EPS as expressed in the peritoneal function. Fourteen patients who had shifted to standard hemodialysis after long-term CAPD (average, 105 months) were studied : 3 developed EPS after PD withdrawal while 11 did not. Analysis of the data obtained from the peritoneal equilibration test (PET) revealed that : (1) the dialysate/plasma creatinine ratio (D/Pcr) was significantly higher in the EPS group than in the non-EPS group during the course of PD as well as after PD withdrawal ; and (2) eight patients, including the 3 with EPS, were classified as being in a high-transport membrane state (HTS) at PD withdrawal. The duration of HTS during PD was longer in those patients with EPS. During the periods after PD withdrawal, none of these EPS patients recovered from HTS, whereas 4 of the 5 non-EPS patients did. These data suggest that long-standing HTS during the course of PD as well as post-withdrawal, may be risk factors for EPS development. For this reason, it is indicated that PET has clinical relevance in examining sequential changes in peritoneal function and in detecting those patients at risk of EPS.
KW - CAPD
KW - Encapsulating peritoneal sclerosis (EPS)
KW - High-transport membrane
KW - Peritoneal equilibration test (PET)
KW - Peritoneal function
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M3 - Article
C2 - 12073625
AN - SCOPUS:0036559297
VL - 44
SP - 396
EP - 402
JO - Japanese Journal of Nephrology
JF - Japanese Journal of Nephrology
SN - 0385-2385
IS - 4
ER -