TY - JOUR
T1 - Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent
AU - Iwai, Kuni
AU - Ido, Tatsuo
AU - Iwata, Ren
AU - Kawamura, Mieko
AU - Kimura, Shuichi
PY - 1989
Y1 - 1989
N2 - [48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.
AB - [48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.
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U2 - 10.1016/0883-2897(89)90162-1
DO - 10.1016/0883-2897(89)90162-1
M3 - Article
C2 - 2621113
AN - SCOPUS:0024819141
VL - 16
SP - 783-787,789
JO - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
JF - International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
SN - 0969-8051
IS - 8
ER -