Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent

Kuni Iwai, Tatsuo Ido, Ren Iwata, Mieko Kawamura, Shuichi Kimura

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    [48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.

    Original languageEnglish
    Pages (from-to)783-787,789
    JournalInternational Journal of Radiation Applications and Instrumentation.
    Volume16
    Issue number8
    DOIs
    Publication statusPublished - 1989

    ASJC Scopus subject areas

    • Medicine(all)

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