Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent

Kuni Iwai; Tatsuo Ido; Ren Iwata; Mieko Kawamura; Shuichi Kimura

doi:10.1016/0883-2897(89)90162-1

Localizing efficiency of [⁴⁸V]vanadyl-pheophorbide in tumor as a new tumor imaging agent

Kuni Iwai, Tatsuo Ido, Ren Iwata, Mieko Kawamura, Shuichi Kimura

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

[⁴⁸V]vanadyl-pheophorbide (⁴⁸V-Pheo) was synthesized by insertion of ⁴⁸V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, ⁴⁸V-Pheo showed a clearer image of an FM3A tumor than inorganic ⁴⁸V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.⁴⁸V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.

Original language	English
Pages (from-to)	783-787,789
Journal	International Journal of Radiation Applications and Instrumentation.
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/0883-2897(89)90162-1
Publication status	Published - 1989

ASJC Scopus subject areas

Medicine(all)

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title = "Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent",

abstract = "[48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.",

author = "Kuni Iwai and Tatsuo Ido and Ren Iwata and Mieko Kawamura and Shuichi Kimura",

year = "1989",

doi = "10.1016/0883-2897(89)90162-1",

language = "English",

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T1 - Localizing efficiency of [48V]vanadyl-pheophorbide in tumor as a new tumor imaging agent

AU - Iwai, Kuni

AU - Ido, Tatsuo

AU - Iwata, Ren

AU - Kawamura, Mieko

AU - Kimura, Shuichi

PY - 1989

Y1 - 1989

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AB - [48V]vanadyl-pheophorbide (48V-Pheo) was synthesized by insertion of 48V into pheophorbide (Pheo), a decomposition product from chlorophyll. At 24 h after injection, 48V-Pheo showed a clearer image of an FM3A tumor than inorganic 48V. This agent also accumulated in MH 134 and S 180 tumors as well as in FM3A tumors. The imaging efficiency was dependent on the affinity of Pheo for tumors.48V-Pheo seems to be suitable as a tumor imaging agent in conjunction with photodynamic therapy.

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