Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI

Huijun Chen, Jianming Cai, Xihai Zhao, Hunter Underhill, Hideki Ota, Minako Oikawa, Li Dong, Chun Yuan, William S. Kerwin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Inflammation plays an important role in progression and rupture of atherosclerotic plaque. Dynamic contrast-enhanced MRI has been proposed as a tool to evaluate inflammation in vivo by measuring the transfer constant and partial plasma volume, which are influenced by inflammation. This study sought to demonstrate the ability of dynamic contrast-enhanced MRI to provide localized measurements of transfer constant and partial plasma volume within plaque regions of different compositions. In order to do that, a highly automatic procedure for localized measurement of dynamic contrast-enhanced MRI parameters was developed. In 47 subjects, the average transfer constant and partial plasma volume were highest in loose matrix and fibrous tissue and substantially lower in intraplaque hemorrhage, lipid rich/necrotic core, and calcification. In addition, except for hemorrhage and calcification, statistically significant differences of transfer constant and partial plasma volume were observed for any pair of these components. This suggests that transfer constant and partial plasma volume could be helpful to differentiate different plaque components and that dynamic contrast-enhanced MRI has the potential to assess inflammatory burden in specific regions.

Original languageEnglish
Pages (from-to)567-573
Number of pages7
JournalMagnetic Resonance in Medicine
Volume64
Issue number2
DOIs
Publication statusPublished - 2010 Aug 1
Externally publishedYes

Keywords

  • Atherosclerosis
  • Carotid artery
  • Dynamic contrast-enhanced MRI
  • Inflammation
  • Kinetic model

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI'. Together they form a unique fingerprint.

  • Cite this

    Chen, H., Cai, J., Zhao, X., Underhill, H., Ota, H., Oikawa, M., Dong, L., Yuan, C., & Kerwin, W. S. (2010). Localized measurement of atherosclerotic plaque inflammatory burden with dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine, 64(2), 567-573. https://doi.org/10.1002/mrm.22369