Localization of PDK-1 mRNA in the brain of developing and adult rats.

S. Yoshida, H. Sakagami, Y. Owada, S. Kokubun, H. Kondo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Gene expression for 3-phosphoinositide-dependent protein kinase-1 (PDK-1) in developing and adult rat brains was examined by in situ hybridization histochemistry. In embryonic days, the mRNA was evident throughout the entire neuraxis. The expression remained evident throughout the entire gray matters until postnatal day 7, and thereafter it decreased overall in the mantle and ventricular zones except for the cerebellar Purkinje and granule cell layers, the olfactory and hippocampal neuronal layers. The pattern of this gene expression is similar to those of for protein kinase B and class I phosphoinositide 3-kinases.

Original languageEnglish
Pages (from-to)249-255
Number of pages7
Journalthe tohoku journal of experimental medicine
Issue number3
Publication statusPublished - 1999 Mar

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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