Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats

Yuji Owada, Masahiko Watanabe, Hisatake Kondo

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A cDNA encoding rat β-adrenergic receptor kinase (β-ARK) was cloned and sequenced. By in situ hybridization histochemistry of adult brain, β-ARK mRNA was expressed intensely in the cerebellar granule cell layer and moderately in the hippocampal pyramidal cells and dentate granule cells. The neocortex and piriform cortex expressed it moderately to weakly, whereas the thalamus and hypothalamus expressed it weakly to faintly. No significant expression of the mRNA was detected in the caudate-putamen. Weak expression of β-ARK mRNA was detected in several nuclei of the brainstem and in the spinal gray matter.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 1992 Sept 14


  • B. Adrenergic receptor kinase
  • Messenger RNA
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)


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