Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats

Yuji Owada; Masahiko Watanabe; Hisatake Kondo

doi:10.1016/0304-3940(92)90704-B

Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats

Yuji Owada, Masahiko Watanabe, Hisatake Kondo

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A cDNA encoding rat β-adrenergic receptor kinase (β-ARK) was cloned and sequenced. By in situ hybridization histochemistry of adult brain, β-ARK mRNA was expressed intensely in the cerebellar granule cell layer and moderately in the hippocampal pyramidal cells and dentate granule cells. The neocortex and piriform cortex expressed it moderately to weakly, whereas the thalamus and hypothalamus expressed it weakly to faintly. No significant expression of the mRNA was detected in the caudate-putamen. Weak expression of β-ARK mRNA was detected in several nuclei of the brainstem and in the spinal gray matter.

Original language	English
Pages (from-to)	9-13
Number of pages	5
Journal	Neuroscience Letters
Volume	144
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(92)90704-B
Publication status	Published - 1992 Sept 14

Keywords

B. Adrenergic receptor kinase
Messenger RNA
Rat

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(92)90704-B

Cite this

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title = "Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats",

abstract = "A cDNA encoding rat β-adrenergic receptor kinase (β-ARK) was cloned and sequenced. By in situ hybridization histochemistry of adult brain, β-ARK mRNA was expressed intensely in the cerebellar granule cell layer and moderately in the hippocampal pyramidal cells and dentate granule cells. The neocortex and piriform cortex expressed it moderately to weakly, whereas the thalamus and hypothalamus expressed it weakly to faintly. No significant expression of the mRNA was detected in the caudate-putamen. Weak expression of β-ARK mRNA was detected in several nuclei of the brainstem and in the spinal gray matter.",

keywords = "B. Adrenergic receptor kinase, Messenger RNA, Rat",

author = "Yuji Owada and Masahiko Watanabe and Hisatake Kondo",

note = "Funding Information: The authors wish to thank Prof. T. Yoshimoto, Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan, for his encouragement through this work. This work was supported by Grant-in-Aid 0440420 for general scientific research to H.K. from the Ministry of Education, Science and Culture in Japan, and the Tanaka Orthopedic Clinic Foundation, Hama-matsu, Japan.",

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doi = "10.1016/0304-3940(92)90704-B",

language = "English",

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T1 - Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats

AU - Owada, Yuji

AU - Watanabe, Masahiko

AU - Kondo, Hisatake

N1 - Funding Information: The authors wish to thank Prof. T. Yoshimoto, Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan, for his encouragement through this work. This work was supported by Grant-in-Aid 0440420 for general scientific research to H.K. from the Ministry of Education, Science and Culture in Japan, and the Tanaka Orthopedic Clinic Foundation, Hama-matsu, Japan.

PY - 1992/9/14

Y1 - 1992/9/14

N2 - A cDNA encoding rat β-adrenergic receptor kinase (β-ARK) was cloned and sequenced. By in situ hybridization histochemistry of adult brain, β-ARK mRNA was expressed intensely in the cerebellar granule cell layer and moderately in the hippocampal pyramidal cells and dentate granule cells. The neocortex and piriform cortex expressed it moderately to weakly, whereas the thalamus and hypothalamus expressed it weakly to faintly. No significant expression of the mRNA was detected in the caudate-putamen. Weak expression of β-ARK mRNA was detected in several nuclei of the brainstem and in the spinal gray matter.

AB - A cDNA encoding rat β-adrenergic receptor kinase (β-ARK) was cloned and sequenced. By in situ hybridization histochemistry of adult brain, β-ARK mRNA was expressed intensely in the cerebellar granule cell layer and moderately in the hippocampal pyramidal cells and dentate granule cells. The neocortex and piriform cortex expressed it moderately to weakly, whereas the thalamus and hypothalamus expressed it weakly to faintly. No significant expression of the mRNA was detected in the caudate-putamen. Weak expression of β-ARK mRNA was detected in several nuclei of the brainstem and in the spinal gray matter.

KW - B. Adrenergic receptor kinase

KW - Messenger RNA

KW - Rat

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Localization of mRNA for β-adrenergic receptor kinase in the brain of adult rats

Abstract

Keywords

ASJC Scopus subject areas

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