Localization of leptin and leptin receptor in the bovine adenohypophysis

Hideki Ogasawara, Shyuichi Ohwada, Yasuhiro Nagai, Yoshikazu Taketa, Masatoshi Matsuzaki, Sachi Tanaka, Kouichi Watanabe, Hisashi Aso, Takahiro Yamaguchi

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of somatotrophs, 15.9% of gonadotrophs, 6.5% of mammotrophs, 6.5% of thyrotrophs and 2.4% of corticotrophs. Both the common short isoform (OBRa) and the long isoform (OBRb) of LepR mRNA were expressed in the bovine adenohypophysis. LepR immunoreactivity (LepR-ir) was found in only 2.8% of the adenohypophysial cells and over 50% of LepR-ir cells were gonadotrophs, in which most of the cells were distributed in the zona tuberalis. The findings on Lep and LepR in the adenohypophysial cells indicate that Lep may regulate gonadotroph function through autocrine/paracrine pathway in the bovine adenohypophysis.

    Original languageEnglish
    Pages (from-to)8-15
    Number of pages8
    JournalDomestic Animal Endocrinology
    Volume35
    Issue number1
    DOIs
    Publication statusPublished - 2008 Jul

    Keywords

    • Adenohypophysial cells
    • Autocrine/paracrine pathway
    • Bovine
    • Leptin
    • Leptin receptor

    ASJC Scopus subject areas

    • Food Animals
    • Animal Science and Zoology
    • Endocrinology

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