Localization of leptin and leptin receptor in the bovine adenohypophysis

Hideki Ogasawara, Shyuichi Ohwada, Yasuhiro Nagai, Yoshikazu Taketa, Masatoshi Matsuzaki, Sachi Tanaka, Kouichi Watanabe, Hisashi Aso, Takahiro Yamaguchi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The present study was carried out to detail the cellular localization of leptin (Lep) and the leptin receptor (LepR) in the bovine adenohypophysis. Lep immunoreactivity (Lep-ir) was found in about 30% of adenohypophysial cells in the gland. Immunochemistry of Lep and specific hormones using serial sections revealed that Lep-ir was present in 60.4% of somatotrophs, 15.9% of gonadotrophs, 6.5% of mammotrophs, 6.5% of thyrotrophs and 2.4% of corticotrophs. Both the common short isoform (OBRa) and the long isoform (OBRb) of LepR mRNA were expressed in the bovine adenohypophysis. LepR immunoreactivity (LepR-ir) was found in only 2.8% of the adenohypophysial cells and over 50% of LepR-ir cells were gonadotrophs, in which most of the cells were distributed in the zona tuberalis. The findings on Lep and LepR in the adenohypophysial cells indicate that Lep may regulate gonadotroph function through autocrine/paracrine pathway in the bovine adenohypophysis.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalDomestic Animal Endocrinology
Volume35
Issue number1
DOIs
Publication statusPublished - 2008 Jul 1

Keywords

  • Adenohypophysial cells
  • Autocrine/paracrine pathway
  • Bovine
  • Leptin
  • Leptin receptor

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology

Fingerprint Dive into the research topics of 'Localization of leptin and leptin receptor in the bovine adenohypophysis'. Together they form a unique fingerprint.

Cite this