Localization of fatty acid binding protein of epidermal type common to dendritic cells and presumptive macrophages in Peyer's patches and epithelial M cells of mouse intestine

Ryoji Suzuki, Mohammad Reza Nourani, Sachiko Saino-Saito, Hiroshi Abe, Tomonori Nochi, Hiroshi Kiyono, Friedrich Spener, Hisatake Kondo, Yuji Owada

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Fatty acid binding protein of epidermal type (E-FABP) was expressed/localized in most, if not all, populations of the dendritic cells in the subepithelial domes, follicles and interfollicular regions of Peyer's patches and presumptive macrophages in their germinal centers, and all M cells in the follicle-associated epithelium of mouse intestine. The immunoreactivity in both of the cell populations makes it easy to recognize the accumulation of DCs in the subepithelial domes in close proximity to the base of M cells, which is essential for luminal antigens to be transported to Peyer's patches. E-FABP may play some important roles in the mucosal immune reaction through Peyer's patches and associated structures.

Original languageEnglish
Pages (from-to)577-584
Number of pages8
JournalHistochemistry and Cell Biology
Volume132
Issue number6
DOIs
Publication statusPublished - 2009 Dec 1
Externally publishedYes

Keywords

  • Dendritic cells
  • E-FABP
  • Immunohistochemistry
  • M cells
  • Mouse
  • Peyer's patch

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Medical Laboratory Technology
  • Cell Biology

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