Localization of epidermal-type fatty acid binding protein in alveolar macrophages and some alveolar type II epithelial cells in mouse lung

Yuji Owada, Soha Abdelkawi Abdelwahab, Ryoji Suzuki, Hiroo Iwasa, Hiroyuki Sakagami, Friedrich Spener, Hisatake Kondo

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Almost all alveolar macrophages in the mouse lung were strongly immunoreactive for epidermal-type fatty acid binding protein. At the electron microscope level, the immunoreactive material was localized diffusely in the cytoplasm but not within the nucleus. A certain number of alveolar type II epithelial cells were also immunoreactive for the protein with variable immunointensity, while a substantial number of the type II cells were immunonegative. No immunoreactive interstitial fibroblasts were encountered. Based on the present findings, possible roles of epidermal-type fatty acid binding protein in the host-defence mechanism played by alveolar macrophages are suggested.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalHistochemical Journal
Volume33
Issue number8
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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