Localization of antigen-presenting cells in Helicobacter pylori-infected gastric mucosa

Tatsuhiko Suzuki, Katsuaki Kato, Shuichi Ohara, Kenji Noguchi, Hitoshi Sekine, Hiroshi Nagura, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Helicobacter pylori (HP) infection is known to induce the specific immune response in the gastric mucosa. The immune response is triggered by presentation of antigen peptides on the major histocompatibility assembly of the antigen-presenting cells (APC) with the assistance of costimulatory molecules such as B7-1 (CD80) and B7-2 (CD86). Their counter-receptors or ligands on T cells are CD28 or cytotoxic lymphocyte-associated molecule-4. The aim of the present study was to clarify the localization of APC and their relation with T cells in HP-infected human gastric mucosa. Our findings suggest that the macrophages in the lamina propria may mainly act as APC in the HP-infected gastric mucosa, and the triggered immune response might be involved in the mucosal immune response in the inflamed gastric mucosa to invasive antigens related to HP organisms.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalPathology international
Volume52
Issue number4
DOIs
Publication statusPublished - 2002

Keywords

  • Antigen-presenting cells
  • CD28
  • Chronic gastritis
  • Costimulatory molecule
  • HLA-DR
  • Helicobacter pylori

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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