Localization and physiological roles of urocortin

Yutaka Oki, Hironobu Sasano

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

Urocortin, a 40 amino acid peptide, is a corticotropin-releasing factor (CRF) related peptide, and can bind to all three types of CRF receptors (CRF type 1, type 2(a) and type 2(b) receptors) with higher affinities for these receptors than CRF. Immunoreactivity of urocortin is widely distributed in central nervous, digestive, cardiovascular, reproductive, immune and endocrine systems. Urocortin plays important roles in appetite-suppression, immunomodulation, steroidogenesis in the ovary, maintenance of the placental function, labor, and cardioprotection via CRF receptors. Although urocortin has potent adrenocorticotropin (ACTH) releasing activity in vitro, endogenous urocortin does not act on pituitary ACTH secretion in vivo.

Original languageEnglish
Pages (from-to)1745-1749
Number of pages5
JournalPeptides
Volume25
Issue number10 SPEC. ISS.
DOIs
Publication statusPublished - 2004 Oct

Keywords

  • CRF receptor
  • Corticotropin-releasing factor
  • Urocortin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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