Local elastic modulus of atherosclerotic lesions of rabbit thoracic aortas and its relation to histology

T. Matsumoto, H. Abe, T. Ohashi, Y. Kato, Masaaki Sato

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Local elastic modulus of atherosclerotic lesions was measured by a pipette aspiration method in thoracic aortas of male Japanese White rabbits fed cholesterol diet for 8, 16, and 24 weeks. Local elastic modulus of the atherosclerotic lesion in the aortic arch was 26.9±2.4 kPa (mean±SEM), 33.1±1.9, and 47.5±3.9 for the 8-, 16-, and 24-week groups, respectively, while that of normal tissue was 38.2±1.7 kPa, indicating that the atherosclerotic lesion is softer than the normal tissue at its initial stage, and then gets stiffer with the progression of the disease. Histological observation showed that the initial lesion was mainly composed of foam cells and the stiffening accompanied the appearance of smooth muscle cells in the sub-intimal region. These results suggest that change in mechanical properties of atherosclerotic lesion is not simple and has a close correlation with its histology.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Number of pages1
ISBN (Print)0780356756
Publication statusPublished - 1999 Dec 1
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: 1999 Oct 131999 Oct 16

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume1
ISSN (Print)0589-1019

Other

OtherProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period99/10/1399/10/16

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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  • Cite this

    Matsumoto, T., Abe, H., Ohashi, T., Kato, Y., & Sato, M. (1999). Local elastic modulus of atherosclerotic lesions of rabbit thoracic aortas and its relation to histology. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 1). IEEE.