Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model

Taigen Nakamura; Ryuta Saito; Shin ichiro Sugiyama; Yukihiko Sonoda; Toshihiro Kumabe; Teiji Tominaga

doi:10.1016/j.canlet.2011.06.018

Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model

Taigen Nakamura, Ryuta Saito, Shin ichiro Sugiyama, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.

Original language	English
Pages (from-to)	77-83
Number of pages	7
Journal	Cancer Letters
Volume	310
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2011.06.018
Publication status	Published - 2011 Nov 1

Keywords

ACNU
Blood-brain barrier
Brain tumor
Convection-enhanced delivery
Local chemotherapy

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2011.06.018

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Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model. / Nakamura, Taigen; Saito, Ryuta; Sugiyama, Shin ichiro et al.

In: Cancer Letters, Vol. 310, No. 1, 01.11.2011, p. 77-83.

Research output: Contribution to journal › Article › peer-review

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title = "Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model",

abstract = "Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.",

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author = "Taigen Nakamura and Ryuta Saito and Sugiyama, {Shin ichiro} and Yukihiko Sonoda and Toshihiro Kumabe and Teiji Tominaga",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare in Japan to R.S. (Grant No. 21791341, 2009). ",

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AU - Sugiyama, Shin ichiro

AU - Sonoda, Yukihiko

AU - Kumabe, Toshihiro

AU - Tominaga, Teiji

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare in Japan to R.S. (Grant No. 21791341, 2009).

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N2 - Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.

AB - Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.

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Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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