Abstract
Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 77-83 |
| Number of pages | 7 |
| Journal | Cancer Letters |
| Volume | 310 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 Nov 1 |
Keywords
- ACNU
- Blood-brain barrier
- Brain tumor
- Convection-enhanced delivery
- Local chemotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Nakamura, T., Saito, R., Sugiyama, S. I., Sonoda, Y., Kumabe, T., & Tominaga, T. (2011). Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model. Cancer Letters, 310(1), 77-83. https://doi.org/10.1016/j.canlet.2011.06.018