Abstract
Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.
Original language | English |
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Pages (from-to) | 77-83 |
Number of pages | 7 |
Journal | Cancer Letters |
Volume | 310 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2011 Nov 1 |
Keywords
- ACNU
- Blood-brain barrier
- Brain tumor
- Convection-enhanced delivery
- Local chemotherapy
ASJC Scopus subject areas
- Oncology
- Cancer Research