Local convection-enhanced delivery of chemotherapeutic agent transiently opens blood-brain barrier and improves efficacy of systemic chemotherapy in intracranial xenograft tumor model

Taigen Nakamura, Ryuta Saito, Shin ichiro Sugiyama, Yukihiko Sonoda, Toshihiro Kumabe, Teiji Tominaga

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Recently, local chemotherapy proved its efficacy against malignant gliomas. Under the hypothesis that local delivery of chemotherapeutic agents into the brain parenchyma induce opening of the blood-brain barrier (BBB), we evaluated the opening of BBB after convection-enhanced delivery of nimustine hydrochloride into the brain parenchyma. Local convection-enhanced delivery of nimustine hydrochloride transiently opened the BBB from about 7-12. days after delivery in normal rodent brain. Systemic chemotherapy during this period of BBB disruption had synergistic effects resulting in prolonged survival of tumor-bearing rats. The present strategy may provide a new approach for glioma chemotherapy.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalCancer Letters
Volume310
Issue number1
DOIs
Publication statusPublished - 2011 Nov 1

Keywords

  • ACNU
  • Blood-brain barrier
  • Brain tumor
  • Convection-enhanced delivery
  • Local chemotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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